Please use this identifier to cite or link to this item:
http://localhost:8080/xmlui/handle/123456789/7357
Title: | Inhibition of Edible Plant Torch Ginger (Etlingera elatior (Jack) R. M. Sm.) against α-Glucosidase and α-Amylase |
Authors: | Syafni, Nova Fakhriadi, Athallah Nofrizal Ismed, Friardi Putra, Deddi Prima |
Keywords: | torch ginger type-2 diabetes mellitus anti-diabetes TLC-autography. |
Issue Date: | Dec-2023 |
Publisher: | Jurnal Sains Farmasi & Klinis |
Citation: | Original Article |
Abstract: | Indonesia's diabetes cases were in the top ten list globally, with 90% of the patients being type-2 diabetes mellitus (T2DM). An approach for screening the local edible plants is made for managing or treating T2DM by inhibiting α-glucosidase and α-amylase enzymes. Results showed that inflorescence of Etlingera elatior inhibition toward both enzymes. TLC-autography and IC50 value of fractions from E. elatior were used to identify the potential fractions and possible compounds for the activity. The non-polar fraction was spotted in the active substances based on TLC-autography. Then, the targeted compounds were separated by column chromatography to obtain stigmasterol as one of the active compounds. The IC50 values of total extract, n-hexane, EtOAc, n-BuOH, and isolated compound against α-glucosidase were 16.0, 7.5, 13.5, 9.7, and 2.0 ppm, respectively. The IC50 values for α-amylase inhibition were respectively 88.6, 48.6, 23.2, 29.1, and 27.5 ppm. The positive control (acarbose) against α-glucosidase and amylase exhibited IC50 values of 153.2 and 12.3 ppm. The inhibition of E. elatior against the two enzymes could be an alternative to delay carbohydrate absorption. |
URI: | http://localhost:8080/xmlui/handle/123456789/7357 |
Appears in Collections: | VOL 10 NO 3 2023 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
348-352.pdf | 570.34 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.