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DC Field | Value | Language |
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dc.contributor.author | Syafni, Nova | - |
dc.contributor.author | Fakhriadi, Athallah | - |
dc.contributor.author | Nofrizal | - |
dc.contributor.author | Ismed, Friardi | - |
dc.contributor.author | Putra, Deddi Prima | - |
dc.date.accessioned | 2024-11-06T07:41:15Z | - |
dc.date.available | 2024-11-06T07:41:15Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.citation | Original Article | en_US |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/7357 | - |
dc.description.abstract | Indonesia's diabetes cases were in the top ten list globally, with 90% of the patients being type-2 diabetes mellitus (T2DM). An approach for screening the local edible plants is made for managing or treating T2DM by inhibiting α-glucosidase and α-amylase enzymes. Results showed that inflorescence of Etlingera elatior inhibition toward both enzymes. TLC-autography and IC50 value of fractions from E. elatior were used to identify the potential fractions and possible compounds for the activity. The non-polar fraction was spotted in the active substances based on TLC-autography. Then, the targeted compounds were separated by column chromatography to obtain stigmasterol as one of the active compounds. The IC50 values of total extract, n-hexane, EtOAc, n-BuOH, and isolated compound against α-glucosidase were 16.0, 7.5, 13.5, 9.7, and 2.0 ppm, respectively. The IC50 values for α-amylase inhibition were respectively 88.6, 48.6, 23.2, 29.1, and 27.5 ppm. The positive control (acarbose) against α-glucosidase and amylase exhibited IC50 values of 153.2 and 12.3 ppm. The inhibition of E. elatior against the two enzymes could be an alternative to delay carbohydrate absorption. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Jurnal Sains Farmasi & Klinis | en_US |
dc.subject | torch ginger | en_US |
dc.subject | type-2 diabetes mellitus | en_US |
dc.subject | anti-diabetes | en_US |
dc.subject | TLC-autography. | en_US |
dc.title | Inhibition of Edible Plant Torch Ginger (Etlingera elatior (Jack) R. M. Sm.) against α-Glucosidase and α-Amylase | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 10 NO 3 2023 |
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File | Description | Size | Format | |
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348-352.pdf | 570.34 kB | Adobe PDF | View/Open |
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