Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7357
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dc.contributor.authorSyafni, Nova-
dc.contributor.authorFakhriadi, Athallah-
dc.contributor.authorNofrizal-
dc.contributor.authorIsmed, Friardi-
dc.contributor.authorPutra, Deddi Prima-
dc.date.accessioned2024-11-06T07:41:15Z-
dc.date.available2024-11-06T07:41:15Z-
dc.date.issued2023-12-
dc.identifier.citationOriginal Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7357-
dc.description.abstractIndonesia's diabetes cases were in the top ten list globally, with 90% of the patients being type-2 diabetes mellitus (T2DM). An approach for screening the local edible plants is made for managing or treating T2DM by inhibiting α-glucosidase and α-amylase enzymes. Results showed that inflorescence of Etlingera elatior inhibition toward both enzymes. TLC-autography and IC50 value of fractions from E. elatior were used to identify the potential fractions and possible compounds for the activity. The non-polar fraction was spotted in the active substances based on TLC-autography. Then, the targeted compounds were separated by column chromatography to obtain stigmasterol as one of the active compounds. The IC50 values of total extract, n-hexane, EtOAc, n-BuOH, and isolated compound against α-glucosidase were 16.0, 7.5, 13.5, 9.7, and 2.0 ppm, respectively. The IC50 values for α-amylase inhibition were respectively 88.6, 48.6, 23.2, 29.1, and 27.5 ppm. The positive control (acarbose) against α-glucosidase and amylase exhibited IC50 values of 153.2 and 12.3 ppm. The inhibition of E. elatior against the two enzymes could be an alternative to delay carbohydrate absorption.en_US
dc.language.isoen_USen_US
dc.publisherJurnal Sains Farmasi & Klinisen_US
dc.subjecttorch gingeren_US
dc.subjecttype-2 diabetes mellitusen_US
dc.subjectanti-diabetesen_US
dc.subjectTLC-autography.en_US
dc.titleInhibition of Edible Plant Torch Ginger (Etlingera elatior (Jack) R. M. Sm.) against α-Glucosidase and α-Amylaseen_US
dc.typeArticleen_US
Appears in Collections:VOL 10 NO 3 2023

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