Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7210
Title: The indirect method in the establishment of reference intervals for complement 3 and complement 4: A retrospective study
Authors: Chai, Jiatong
Sun, Zeyu
Xing, Dongyang
Zhou, Qi
Xu, Jiancheng
Keywords: China
Data mining
Indirect method
Reference intervals
Serum complement 3
Serum complement 4
Issue Date: 2022
Publisher: Journal of Taibah University Medical Sciences
Series/Report no.: Original Article;353-361
Abstract: Objective: The establishment of reference intervals (RIs) for complement 3 (C3) and complement 4 (C4) is rare, especially by indirect methods. Therefore, this study aims to establish regional RIs for C3 and C4 by an indirect method, using relevant statistical methods. Methods: Total of 12,313 data points for C3 and 12,125 data points for C4 were obtained from the First Hospital of Jilin University’s database in China and standardised using the Tukey and BoxeCox statistical methods. The coefficients of the skewness-median-coefficient of variation curves (LMS) were used to determine the critical value for age, and a subsequent z test used to compare the differences. A non-parametric method was used to establish the RIs. Results: The C3 and C4 concentrations showed no significant differences by sex, and a weak correlation with age. No significant difference was found after calculating the z value for the age points on the LMS curves. The RIs for C3 and C4 were 0.83e1.58 g/L and 0.15e0.40 g/L, respectively. The RIs all passed verification. Conclusion: Suitable RIs for C3 and C4 were established for the local population, and will benefit clinical diagnosis. The feasibility and practicability of the indirect method were demonstrated.
URI: http://localhost:8080/xmlui/handle/123456789/7210
ISSN: 1658-3612
Appears in Collections:Vol 17 No 3 (2022)

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