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dc.contributor.authorChai, Jiatong-
dc.contributor.authorSun, Zeyu-
dc.contributor.authorXing, Dongyang-
dc.contributor.authorZhou, Qi-
dc.contributor.authorXu, Jiancheng-
dc.date.accessioned2024-11-01T03:46:26Z-
dc.date.available2024-11-01T03:46:26Z-
dc.date.issued2022-
dc.identifier.issn1658-3612-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7210-
dc.description.abstractObjective: The establishment of reference intervals (RIs) for complement 3 (C3) and complement 4 (C4) is rare, especially by indirect methods. Therefore, this study aims to establish regional RIs for C3 and C4 by an indirect method, using relevant statistical methods. Methods: Total of 12,313 data points for C3 and 12,125 data points for C4 were obtained from the First Hospital of Jilin University’s database in China and standardised using the Tukey and BoxeCox statistical methods. The coefficients of the skewness-median-coefficient of variation curves (LMS) were used to determine the critical value for age, and a subsequent z test used to compare the differences. A non-parametric method was used to establish the RIs. Results: The C3 and C4 concentrations showed no significant differences by sex, and a weak correlation with age. No significant difference was found after calculating the z value for the age points on the LMS curves. The RIs for C3 and C4 were 0.83e1.58 g/L and 0.15e0.40 g/L, respectively. The RIs all passed verification. Conclusion: Suitable RIs for C3 and C4 were established for the local population, and will benefit clinical diagnosis. The feasibility and practicability of the indirect method were demonstrated.en_US
dc.language.isoen_USen_US
dc.publisherJournal of Taibah University Medical Sciencesen_US
dc.relation.ispartofseriesOriginal Article;353-361-
dc.subjectChinaen_US
dc.subjectData miningen_US
dc.subjectIndirect methoden_US
dc.subjectReference intervalsen_US
dc.subjectSerum complement 3en_US
dc.subjectSerum complement 4en_US
dc.titleThe indirect method in the establishment of reference intervals for complement 3 and complement 4: A retrospective studyen_US
dc.typeArticleen_US
Appears in Collections:Vol 17 No 3 (2022)

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