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dc.contributor.author-Rong Jheng, Jia-
dc.contributor.author-Fan Hsieh, Chung-
dc.contributor.author-Hsiu Chang, Yu-
dc.contributor.author-Yuan Ho, Jin-
dc.contributor.authorFang Tang, Wen--
dc.contributor.authorChen, Zi-Yi-
dc.contributor.author-Jou Liu, Chien-
dc.date.accessioned2024-12-19T02:23:35Z-
dc.date.available2024-12-19T02:23:35Z-
dc.date.issued2022-08-01-
dc.identifier.issn1684-1182-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9262-
dc.description.abstractAbstract Background: The purpose of this study was to examine the in vivo activity of rosmarinic acid (RA) e a phytochemical with antioxidant, anti-inflammatory, and antiviral properties e against influenza virus (IAV). An antibody-based kinase array and different in vitro functional assays were also applied to identify the mechanistic underpinnings by which RA may exert its anti-IAV activity.Methods: We initially examined the potential efficacy of RA using an in vivo mouse model. A time-of-addition assay and an antibody-based kinase array were subsequently applied to investigate mechanism-of-action targets for RA. The hemagglutination inhibition assay, neuraminidase inhibition assay, and cellular entry assay were also performed. Results: RA increased survival and prevented body weight loss in IAV-infected mice. In vitro experiments revealed that RA inhibited different IAV viruses e including oseltamivirresistant strains. From a mechanistic point of view, RA downregulated the GSK3b and Akt signaling pathways e which are known to facilitate IAV entry and replication into host cells. Conclusions: RA has promising preclinical efficacy against IAV, primarily by interfering with the GSK3b and Akt signaling pathways.en_US
dc.language.isoenen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectAkt;en_US
dc.subjectGSK3b;en_US
dc.subjectInfluenza virus A;en_US
dc.subjectRosmarinic acid;en_US
dc.subjectSignaling pathwaysen_US
dc.titleRosmarinic acid interferes with influenza virus A entry and replication by decreasing GSK3b and phosphorylated AKT expression levelsen_US
dc.typeArticleen_US
Appears in Collections:VOL 55 NO 4 2022

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