DDX3X structural analysis: Implications in the pharmacology and innate immunity

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DC Field	Value	Language
dc.contributor.author	De Colibus, Luigi	-
dc.contributor.author	Stunnenberg, Melissa	-
dc.contributor.author	B.H. Geijtenbeek, Teunis	-
dc.date.accessioned	2024-12-17T02:46:21Z	-
dc.date.available	2024-12-17T02:46:21Z	-
dc.date.issued	2022	-
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/9132	-
dc.description.abstract	The human DEAD-Box Helicase 3 X-Linked (DDX3X) is an ATP-dependent RNA helicase involved in virtually every step of RNA metabolism, ranging from transcription regulation in the nucleus to translation initiation and stress granule (SG) formation, and plays crucial roles in innate immunity, as well as tumorigenesis and viral infections. This review discusses latest advances in DDX3X biology and structure-function relationship, including the implications of the recent DDX3X crystal structure in complex with double stranded RNA for RNA metabolism, DDX3X involvement in the cross-talk between innate immune responses and cell stress adaptation, and the roles of DDX3X in controlling cell fate	en_US
dc.subject	Helicase DDX3X MAVS Inflammasome RIGI RNA	en_US
dc.title	DDX3X structural analysis: Implications in the pharmacology and innate immunity	en_US
dc.type	Article	en_US
Appears in Collections:	VOL 3 2022

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