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Title: | Interdependence of glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agents |
Authors: | Cheng, Pin-Nan Sun, Hung-Yu Feng, I-Che Chiu, Yen-Cheng Wang, Sin-Tian Tan, Dyoness Charmaine |
Keywords: | Glycemic parameters Hepatitis C virus Lipid metabolism Post-therapy Sustained virological response |
Issue Date: | Feb-2024 |
Publisher: | Journal of Microbiology, Immunology and Infection |
Citation: | Original Article |
Abstract: | Abstract Background: Chronic hepatitis C virus (HCV) infection causes various liver diseases and metabolic disorders. With direct-acting antiviral agents (DAAs), which effectively eradicate pan-genotypic HCV, hepatic and concomitant metabolic restorations are achieved. The study aims to evaluate the posttherapeutic benefits of lipid and glycemic homeostasis. Methods: Nighty-five chronic hepatitis C patients who achieved sustained virological response (SVR) by using DAAs were enrolled to collect plasma samples and fractionated lipoproteins at baseline, SVR, and during the post-SVR follow-ups for 6 months (pS6m) and 1 year (pS1yr). The lipid and glycemic parameters were analyzed to establish muturally modulatory relationships. Results: Plasma cholesterol (Chol) and glucose were elevated at SVR from baseline, whereas plasma Chol remained increased until pS1yr; however, glucose returned to the basal level. The post-SVR responses included a peak elevation of glycated hemoglobin at pS6m, a sustained elevation of triglyceride (Tg), and sustained declines in insulin, homeostasis model assessment HOMA)-insulin resistance, and HOMA-beta levels until pS1yr. The changes in plasma Chol and high-density-lipoprotein Chol showed positive correlations, as did the plasma Tg with lowdensity-lipoprotein Tg and very-low-density-lipoprotein Tg per particle load. Very-lowdensity-lipoprotein was found to be loaded with increased Tg and Chol and underwent efficient Tg catabolism in the form of conversion into low-density-lipoprotein. Additionally, the posttherapeutic dynamics exhibited correlations of high-density-lipoprotein Chol with plasma glucose and HOMA-beta. Conclusion: Irrespective of the baseline metabolic status, the posttherapeutic interdependent modulation of blood glycemic and lipid metabolic parameters were revealed in chronic hepatitis C patients following clearance of HCV viremia by DAA treatment. |
URI: | http://localhost:8080/xmlui/handle/123456789/9103 |
Appears in Collections: | VOL 56 NO 1 2023 |
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