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dc.contributor.authorCheng, Pin-Nan-
dc.contributor.authorSun, Hung-Yu-
dc.contributor.authorFeng, I-Che-
dc.contributor.authorChiu, Yen-Cheng-
dc.contributor.authorWang, Sin-Tian-
dc.contributor.authorTan, Dyoness Charmaine-
dc.date.accessioned2024-12-16T03:39:08Z-
dc.date.available2024-12-16T03:39:08Z-
dc.date.issued2024-02-
dc.identifier.citationOriginal Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9103-
dc.description.abstractAbstract Background: Chronic hepatitis C virus (HCV) infection causes various liver diseases and metabolic disorders. With direct-acting antiviral agents (DAAs), which effectively eradicate pan-genotypic HCV, hepatic and concomitant metabolic restorations are achieved. The study aims to evaluate the posttherapeutic benefits of lipid and glycemic homeostasis. Methods: Nighty-five chronic hepatitis C patients who achieved sustained virological response (SVR) by using DAAs were enrolled to collect plasma samples and fractionated lipoproteins at baseline, SVR, and during the post-SVR follow-ups for 6 months (pS6m) and 1 year (pS1yr). The lipid and glycemic parameters were analyzed to establish muturally modulatory relationships. Results: Plasma cholesterol (Chol) and glucose were elevated at SVR from baseline, whereas plasma Chol remained increased until pS1yr; however, glucose returned to the basal level. The post-SVR responses included a peak elevation of glycated hemoglobin at pS6m, a sustained elevation of triglyceride (Tg), and sustained declines in insulin, homeostasis model assessment HOMA)-insulin resistance, and HOMA-beta levels until pS1yr. The changes in plasma Chol and high-density-lipoprotein Chol showed positive correlations, as did the plasma Tg with lowdensity-lipoprotein Tg and very-low-density-lipoprotein Tg per particle load. Very-lowdensity-lipoprotein was found to be loaded with increased Tg and Chol and underwent efficient Tg catabolism in the form of conversion into low-density-lipoprotein. Additionally, the posttherapeutic dynamics exhibited correlations of high-density-lipoprotein Chol with plasma glucose and HOMA-beta. Conclusion: Irrespective of the baseline metabolic status, the posttherapeutic interdependent modulation of blood glycemic and lipid metabolic parameters were revealed in chronic hepatitis C patients following clearance of HCV viremia by DAA treatment.en_US
dc.language.isoen_USen_US
dc.publisherJournal of Microbiology, Immunology and Infectionen_US
dc.subjectGlycemic parametersen_US
dc.subjectHepatitis C virusen_US
dc.subjectLipid metabolismen_US
dc.subjectPost-therapyen_US
dc.subjectSustained virological responseen_US
dc.titleInterdependence of glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agentsen_US
dc.typeArticleen_US
Appears in Collections:VOL 56 NO 1 2023

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