Please use this identifier to cite or link to this item:
http://localhost:8080/xmlui/handle/123456789/7948
Title: | Effect of papaya flower ethanolic extract (Carica papaya) on the time kill of tetracyclin against Escherichia coli |
Authors: | Anugraheni Rini, Chylen Setiyo |
Keywords: | Papaya flowers (Carica papaya) Escherichia coli MIC Time-kill test |
Issue Date: | Jul-2023 |
Publisher: | Pharmaciana |
Abstract: | Papaya (Carica papaya) is found throughout Indonesia. Papaya flowers contain saponin, tannin, alkaloid, and flavonoid compounds which functions as antibacterial. Escherichia coli is a Gram-negative rod bacteria that could be found in the human large intestine as a cause of diarrhea. The study aimed to determine the effect of papaya flower extract and a combination of papaya flower extract with tetracycline antibiotics using the smallest concentration capable of inhibiting 50% of bacterial growth against Escherichia coli bacteria ATCC 25922 using the time-kill test method. This study used the method of Minimum Inhibitory Concentration (MIC) and time-kill. The MIC of the ethanol extract of papaya flower was 2 mg/mL. The time-kill test showed that the death phase was occurred at 4 - 24 hours. The bacteriostatic effect of the extract was obtained at 0 hours to 24 hours, while the antibiotic and its combination with the extracts had a bactericidal effect at 8 hours and 24 hours. |
URI: | http://localhost:8080/xmlui/handle/123456789/7948 |
ISSN: | 2088 4559 |
Appears in Collections: | VOL 13 NO 2 2023 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
246+–+256.pdf | 515.97 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.