Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7902
Title: Formulation of patchouli oil spray gel (Pogostemon cablin Benth) and irritation test in rabbit
Authors: Herowet, Junvidya
Rochman, M. Fatchur
Fitriani, Nurlaeli
Dinda, Safira
Keywords: pogestemon oil
erythema
edema
topical
dermal irritation
Issue Date: Mar-2023
Publisher: Pharmaciana
Abstract: Patchouli plant (Pogostemon cablin Benth) is one of the essential oil-producing plants widely used in perfume, cosmetic, aromatherapy, antiseptic, antibacterial, and antifungal industries. The essential oil derived from patchouli leaves contains terpenoid compounds with antibacterial and antifungal activity. This study aims to determine the optimum formulation of patchouli oil spray gel as a wound antiseptic and to observe the irritation test of the samples. The spray gel formulations of patchouli oil were prepared in various concentrations i.e. 5%, 7.5%, and 10% (v/v), solved in aquadest with the addition of carbopol 940 as the gelating agent. The spray gels were tested to determine their physical characteristics, including the organoleptic test, homogeneity test, pH, adhesive dispersion test, viscosity test, and spray pattern test. The results showed that the patchouli oil spray gels were yellowish-white and had a distinctive odor and homogeneous texture with a pH 5. They all had adhesive dispersion, and the optimum viscosity of the spray gel was found at a 7.5% (v/v) concentration of patchouli oil. The irritation test was carried out using the patch test method with a score of erythema and edema. The results showed that all three formulas very mild irritation.
URI: http://localhost:8080/xmlui/handle/123456789/7902
ISSN: 2088 4559
Appears in Collections:VOL 13 NO 1 2023

Files in This Item:
File Description SizeFormat 
38-47.pdf419.04 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.