Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7715
Title: Interleukin 1 beta and its association with the periodontal health of pregnant women
Authors: Hassan, Nawal K.B. El
Ramadan, AbdelRahman M.
Keywords: Interleukin-1 beta
Periodontal disease
Pregnancy
Sudan
Issue Date: 2023
Publisher: Journal of Taibah University Medical Sciences
Series/Report no.: Original Article;1376-1383
Abstract: Objectives: In this study, we measured and compared serum and gingival crevicular fluid (GCF) levels of interleukin 1 beta (IL-1b) in pregnant women with periodontitis and pregnant women with a healthy periodontium. We also determined the prevalence of periodontitis among pregnant women attending Omdurman Midwifery Hospital. Materials: This was a hospital-based clinical study and laboratory investigation using ELISA tests of 80 pregnant women in the third trimester conducted at the Omdurman Midwifery Hospital in Khartoum, Sudan. The study group consisted of 50 women while the control group consisted of 30 women. Results: Independent samples t-tests were used to compare serum and GCF levels of IL-1b between the study and control groups. Pearson’s correlation analysis was also used to compare gingival parameters and IL-1b levels in the GCF. For each comparison, the p-value was fixed at 0.05. The GCF in the research group showed a considerable increase in IL-1b levels. There was also a strong positive association between high IL-1b levels in the research group’s GCF and probing pocket depth (PPD) and clinical attachment level (CAL) levels. Conclusions: Our study provides further evidence that periodontitis, as measured by a PD 4 mm and a CAL 3 mm, is associated with an increased level of IL-1b in the GCF of pregnant women with active periodontal disease during pregnancy and may include the transient translocation of oral organisms to the utero-placental unit, inciting placental inflammation or oxidative stress early in pregnancy, ultimately resulting in placental damage and clinical manifestations
URI: http://localhost:8080/xmlui/handle/123456789/7715
ISSN: 1658-3612
Appears in Collections:Vol 18 No 6 (2023)

Files in This Item:
File Description SizeFormat 
1376-1383.pdf1.08 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.