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dc.contributor.authorHassan, Nawal K.B. El-
dc.contributor.authorRamadan, AbdelRahman M.-
dc.date.accessioned2024-11-11T02:48:07Z-
dc.date.available2024-11-11T02:48:07Z-
dc.date.issued2023-
dc.identifier.issn1658-3612-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7715-
dc.description.abstractObjectives: In this study, we measured and compared serum and gingival crevicular fluid (GCF) levels of interleukin 1 beta (IL-1b) in pregnant women with periodontitis and pregnant women with a healthy periodontium. We also determined the prevalence of periodontitis among pregnant women attending Omdurman Midwifery Hospital. Materials: This was a hospital-based clinical study and laboratory investigation using ELISA tests of 80 pregnant women in the third trimester conducted at the Omdurman Midwifery Hospital in Khartoum, Sudan. The study group consisted of 50 women while the control group consisted of 30 women. Results: Independent samples t-tests were used to compare serum and GCF levels of IL-1b between the study and control groups. Pearson’s correlation analysis was also used to compare gingival parameters and IL-1b levels in the GCF. For each comparison, the p-value was fixed at 0.05. The GCF in the research group showed a considerable increase in IL-1b levels. There was also a strong positive association between high IL-1b levels in the research group’s GCF and probing pocket depth (PPD) and clinical attachment level (CAL) levels. Conclusions: Our study provides further evidence that periodontitis, as measured by a PD 4 mm and a CAL 3 mm, is associated with an increased level of IL-1b in the GCF of pregnant women with active periodontal disease during pregnancy and may include the transient translocation of oral organisms to the utero-placental unit, inciting placental inflammation or oxidative stress early in pregnancy, ultimately resulting in placental damage and clinical manifestationsen_US
dc.language.isoen_USen_US
dc.publisherJournal of Taibah University Medical Sciencesen_US
dc.relation.ispartofseriesOriginal Article;1376-1383-
dc.subjectInterleukin-1 betaen_US
dc.subjectPeriodontal diseaseen_US
dc.subjectPregnancyen_US
dc.subjectSudanen_US
dc.titleInterleukin 1 beta and its association with the periodontal health of pregnant womenen_US
dc.typeArticleen_US
Appears in Collections:Vol 18 No 6 (2023)

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