Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7704
Title: Applications of Metformin in Dentistryd-A review
Authors: Uddin, Muhammad Khawaja Hammad
Sadiq, Muhammad Shahrukh Khan
Ahmed, Ashfaq
dkk.
Keywords: Metformin
Periodontitis
Carcinoma
Squamous cell
Stem cells
Osseointegration
Orthodontics
Photochemotherapy
Issue Date: 2023
Publisher: Journal of Taibah University Medical Sciences
Series/Report no.: Review Article;1299-1310
Abstract: Metformin is a versatile drug with numerous medical uses. It is known primarily as an anti-hyperglycemic drug that has become the main oral blood-glucose-lowering medication for managing type 2 diabetes mellitus globally. Its use has been reported in a variety of oral conditions and dentistry in general. Recent clinical trials have indicated the effectiveness of adjunct topical application of metformin in improving the periodontal parameters of patients with diabetes and periodontitis. Additionally, studies have suggested that metformin stimulates odontogenic differentiation and mineral synthesis of stem cells in the tooth pulp. Metformin also stimulates osteoblast proliferation, decreases osteoclast activity and exerts regenerative effects on periodontal bone, thus making it a viable candidate for periodontal regeneration. Metformin monotherapy significantly enhances osseointegration of endosseous implants and has been reported to have anticancer effects on oral squamous cell carcinoma by impeding tumor progression. Animal studies have indicated that metformin improves orthodontic tooth movement and resists orthodontic appliance corrosion. This narrative review aims to provide a current summary of research highlighting the prospective uses of metformin in dentistry.
URI: http://localhost:8080/xmlui/handle/123456789/7704
ISSN: 1658-3612
Appears in Collections:Vol 18 No 6 (2023)

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