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Title: | Applications of Metformin in Dentistryd-A review |
Authors: | Uddin, Muhammad Khawaja Hammad Sadiq, Muhammad Shahrukh Khan Ahmed, Ashfaq dkk. |
Keywords: | Metformin Periodontitis Carcinoma Squamous cell Stem cells Osseointegration Orthodontics Photochemotherapy |
Issue Date: | 2023 |
Publisher: | Journal of Taibah University Medical Sciences |
Series/Report no.: | Review Article;1299-1310 |
Abstract: | Metformin is a versatile drug with numerous medical uses. It is known primarily as an anti-hyperglycemic drug that has become the main oral blood-glucose-lowering medication for managing type 2 diabetes mellitus globally. Its use has been reported in a variety of oral conditions and dentistry in general. Recent clinical trials have indicated the effectiveness of adjunct topical application of metformin in improving the periodontal parameters of patients with diabetes and periodontitis. Additionally, studies have suggested that metformin stimulates odontogenic differentiation and mineral synthesis of stem cells in the tooth pulp. Metformin also stimulates osteoblast proliferation, decreases osteoclast activity and exerts regenerative effects on periodontal bone, thus making it a viable candidate for periodontal regeneration. Metformin monotherapy significantly enhances osseointegration of endosseous implants and has been reported to have anticancer effects on oral squamous cell carcinoma by impeding tumor progression. Animal studies have indicated that metformin improves orthodontic tooth movement and resists orthodontic appliance corrosion. This narrative review aims to provide a current summary of research highlighting the prospective uses of metformin in dentistry. |
URI: | http://localhost:8080/xmlui/handle/123456789/7704 |
ISSN: | 1658-3612 |
Appears in Collections: | Vol 18 No 6 (2023) |
Files in This Item:
File | Description | Size | Format | |
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1299-1310.pdf | 1.93 MB | Adobe PDF | View/Open |
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