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dc.contributor.authorUddin, Muhammad Khawaja Hammad-
dc.contributor.authorSadiq, Muhammad Shahrukh Khan-
dc.contributor.authorAhmed, Ashfaq-
dc.contributor.authordkk.-
dc.date.accessioned2024-11-11T02:33:44Z-
dc.date.available2024-11-11T02:33:44Z-
dc.date.issued2023-
dc.identifier.issn1658-3612-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7704-
dc.description.abstractMetformin is a versatile drug with numerous medical uses. It is known primarily as an anti-hyperglycemic drug that has become the main oral blood-glucose-lowering medication for managing type 2 diabetes mellitus globally. Its use has been reported in a variety of oral conditions and dentistry in general. Recent clinical trials have indicated the effectiveness of adjunct topical application of metformin in improving the periodontal parameters of patients with diabetes and periodontitis. Additionally, studies have suggested that metformin stimulates odontogenic differentiation and mineral synthesis of stem cells in the tooth pulp. Metformin also stimulates osteoblast proliferation, decreases osteoclast activity and exerts regenerative effects on periodontal bone, thus making it a viable candidate for periodontal regeneration. Metformin monotherapy significantly enhances osseointegration of endosseous implants and has been reported to have anticancer effects on oral squamous cell carcinoma by impeding tumor progression. Animal studies have indicated that metformin improves orthodontic tooth movement and resists orthodontic appliance corrosion. This narrative review aims to provide a current summary of research highlighting the prospective uses of metformin in dentistry.en_US
dc.language.isoen_USen_US
dc.publisherJournal of Taibah University Medical Sciencesen_US
dc.relation.ispartofseriesReview Article;1299-1310-
dc.subjectMetforminen_US
dc.subjectPeriodontitisen_US
dc.subjectCarcinomaen_US
dc.subjectSquamous cellen_US
dc.subjectStem cellsen_US
dc.subjectOsseointegrationen_US
dc.subjectOrthodonticsen_US
dc.subjectPhotochemotherapyen_US
dc.titleApplications of Metformin in Dentistryd-A reviewen_US
dc.typeArticleen_US
Appears in Collections:Vol 18 No 6 (2023)

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