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Title: | Antiviral Activity of an Extract from Leaves of the Tropical Plant Cynometra cauliflora |
Authors: | Wahab, Noor Zarina Abd Azizul, Aziah Badya, Norhidayah Nazlina, Ibrahim |
Keywords: | Herpes simplex virus type 1 Cynometra cauliflora plaque reduction assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) virucidal. |
Issue Date: | May-2021 |
Publisher: | Pharmacogn J. |
Citation: | Research Article |
Abstract: | Background: Cynometra cauliflora is a species of tree in the family Fabaceae and has been used in folk medicinal preparation. Objectives: In this study, Cynometra cauliflora methanolic leaves extract was tested against clinical isolate herpes simplex virus type-1 (HSV-1). Materials and Methods: The leaves of C. cauliflora plant was extracted using methanol extraction method. Cytotoxicity was assessed using 3-(4,5-dimethylthiazol-2,5-diphenyltetrazolium bromide (MTT) assay. Plaque reduction assays were carried out to evaluate the antiviral activity of C. cauliflora extract against HSV-1. These include post-treatment, pre-treatment and virucidal assays. Results: The value of cytotoxic concentration, CC50 of C. cauliflora extract was 36 mg/ mL. High antiviral activity was observed in post-treatment. C. cauliflora extract treatment was found to not interfere directly to infectious particle and confer mild protection when given as prophylaxis. Conclusion: This study provides important novel insights on the phytomedicinal properties of C. cauliflora extracts on HSV-1. |
URI: | http://localhost:8080/xmlui/handle/123456789/7463 |
Appears in Collections: | VOL 13 NO 3 2021 |
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