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DC Field | Value | Language |
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dc.contributor.author | Wahab, Noor Zarina Abd | - |
dc.contributor.author | Azizul, Aziah | - |
dc.contributor.author | Badya, Norhidayah | - |
dc.contributor.author | Nazlina, Ibrahim | - |
dc.date.accessioned | 2024-11-07T03:42:26Z | - |
dc.date.available | 2024-11-07T03:42:26Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.citation | Research Article | en_US |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/7463 | - |
dc.description.abstract | Background: Cynometra cauliflora is a species of tree in the family Fabaceae and has been used in folk medicinal preparation. Objectives: In this study, Cynometra cauliflora methanolic leaves extract was tested against clinical isolate herpes simplex virus type-1 (HSV-1). Materials and Methods: The leaves of C. cauliflora plant was extracted using methanol extraction method. Cytotoxicity was assessed using 3-(4,5-dimethylthiazol-2,5-diphenyltetrazolium bromide (MTT) assay. Plaque reduction assays were carried out to evaluate the antiviral activity of C. cauliflora extract against HSV-1. These include post-treatment, pre-treatment and virucidal assays. Results: The value of cytotoxic concentration, CC50 of C. cauliflora extract was 36 mg/ mL. High antiviral activity was observed in post-treatment. C. cauliflora extract treatment was found to not interfere directly to infectious particle and confer mild protection when given as prophylaxis. Conclusion: This study provides important novel insights on the phytomedicinal properties of C. cauliflora extracts on HSV-1. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Pharmacogn J. | en_US |
dc.subject | Herpes simplex virus type 1 | en_US |
dc.subject | Cynometra cauliflora | en_US |
dc.subject | plaque reduction assay | en_US |
dc.subject | (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) | en_US |
dc.subject | virucidal. | en_US |
dc.title | Antiviral Activity of an Extract from Leaves of the Tropical Plant Cynometra cauliflora | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 13 NO 3 2021 |
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