Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7463
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dc.contributor.authorWahab, Noor Zarina Abd-
dc.contributor.authorAzizul, Aziah-
dc.contributor.authorBadya, Norhidayah-
dc.contributor.authorNazlina, Ibrahim-
dc.date.accessioned2024-11-07T03:42:26Z-
dc.date.available2024-11-07T03:42:26Z-
dc.date.issued2021-05-
dc.identifier.citationResearch Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7463-
dc.description.abstractBackground: Cynometra cauliflora is a species of tree in the family Fabaceae and has been used in folk medicinal preparation. Objectives: In this study, Cynometra cauliflora methanolic leaves extract was tested against clinical isolate herpes simplex virus type-1 (HSV-1). Materials and Methods: The leaves of C. cauliflora plant was extracted using methanol extraction method. Cytotoxicity was assessed using 3-(4,5-dimethylthiazol-2,5-diphenyltetrazolium bromide (MTT) assay. Plaque reduction assays were carried out to evaluate the antiviral activity of C. cauliflora extract against HSV-1. These include post-treatment, pre-treatment and virucidal assays. Results: The value of cytotoxic concentration, CC50 of C. cauliflora extract was 36 mg/ mL. High antiviral activity was observed in post-treatment. C. cauliflora extract treatment was found to not interfere directly to infectious particle and confer mild protection when given as prophylaxis. Conclusion: This study provides important novel insights on the phytomedicinal properties of C. cauliflora extracts on HSV-1.en_US
dc.language.isoen_USen_US
dc.publisherPharmacogn J.en_US
dc.subjectHerpes simplex virus type 1en_US
dc.subjectCynometra caulifloraen_US
dc.subjectplaque reduction assayen_US
dc.subject(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)en_US
dc.subjectvirucidal.en_US
dc.titleAntiviral Activity of an Extract from Leaves of the Tropical Plant Cynometra caulifloraen_US
dc.typeArticleen_US
Appears in Collections:VOL 13 NO 3 2021

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