Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7462
Title: Antihypertensive Effects of Osteospermum Imbricatum in Two Hypertensive Rat Models
Authors: Tata, Charlotte Mungho
Sewani-Rusike, Constance Rufaro
Aremu, Olukayode
Oyedej, Opeoluwa Oyehan
Nkeh-Chungag, Benedicta Ngwenchi
Keywords: Antioxidants
High blood pressure
Nω-Nitro-L-arginine methyl ester
Spontaneously hypertensive rats
Issue Date: May-2021
Publisher: Pharmacogn J.
Citation: Research Article
Abstract: Introduction: Osteospermum imbricatum is used traditionally in Eastern Cape, South Africa for the management of hypertension, chest and stomach complaints. This study was aimed at investigating the antioxidant and antihypertensive effects of this plant. Methods: Antioxidant capacity was determined by radical scavenging assays and ferric reducing antioxidant power. Antihypertensive effects after once off treatment with the leaf/root extracts (500 mg/kg) were evaluated in spontaneously hypertensive rats (SHR). The effect of the extracts on established hypertension was determined in Wistar rats treated with Nω-Nitro-L-arginine methyl ester (L-NAME) (40 mg/kg/day) for 4 weeks followed by co-treatment with L-NAME and extracts (200 mg/kg and 400 mg/kg) or amlodipine (5 mg/kg) or normal saline for 4 more weeks. Results: The concentration at which there was 50 % inhibition (IC50) of DPPH radical by the extracts was lower for the leaf extract (0.79 mg/mL) compared to the root extract (1.15 mg/mL). The leaf extract significantly (p<0.01) decreased systolic and diastolic blood pressures in both rat models. Conclusion: The extracts of Osteospermum imbricatum have moderate antioxidants and antihypertensive properties.
URI: http://localhost:8080/xmlui/handle/123456789/7462
Appears in Collections:VOL 13 NO 3 2021

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