Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7462
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTata, Charlotte Mungho-
dc.contributor.authorSewani-Rusike, Constance Rufaro-
dc.contributor.authorAremu, Olukayode-
dc.contributor.authorOyedej, Opeoluwa Oyehan-
dc.contributor.authorNkeh-Chungag, Benedicta Ngwenchi-
dc.date.accessioned2024-11-07T03:39:19Z-
dc.date.available2024-11-07T03:39:19Z-
dc.date.issued2021-05-
dc.identifier.citationResearch Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7462-
dc.description.abstractIntroduction: Osteospermum imbricatum is used traditionally in Eastern Cape, South Africa for the management of hypertension, chest and stomach complaints. This study was aimed at investigating the antioxidant and antihypertensive effects of this plant. Methods: Antioxidant capacity was determined by radical scavenging assays and ferric reducing antioxidant power. Antihypertensive effects after once off treatment with the leaf/root extracts (500 mg/kg) were evaluated in spontaneously hypertensive rats (SHR). The effect of the extracts on established hypertension was determined in Wistar rats treated with Nω-Nitro-L-arginine methyl ester (L-NAME) (40 mg/kg/day) for 4 weeks followed by co-treatment with L-NAME and extracts (200 mg/kg and 400 mg/kg) or amlodipine (5 mg/kg) or normal saline for 4 more weeks. Results: The concentration at which there was 50 % inhibition (IC50) of DPPH radical by the extracts was lower for the leaf extract (0.79 mg/mL) compared to the root extract (1.15 mg/mL). The leaf extract significantly (p<0.01) decreased systolic and diastolic blood pressures in both rat models. Conclusion: The extracts of Osteospermum imbricatum have moderate antioxidants and antihypertensive properties.en_US
dc.language.isoen_USen_US
dc.publisherPharmacogn J.en_US
dc.subjectAntioxidantsen_US
dc.subjectHigh blood pressureen_US
dc.subjectNω-Nitro-L-arginine methyl esteren_US
dc.subjectSpontaneously hypertensive ratsen_US
dc.titleAntihypertensive Effects of Osteospermum Imbricatum in Two Hypertensive Rat Modelsen_US
dc.typeArticleen_US
Appears in Collections:VOL 13 NO 3 2021

Files in This Item:
File Description SizeFormat 
19.pdf508.63 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.