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Title: | Characterization and Acute Toxicity Bioactive Compound Canning Waste of Lemuru Fish Oil as Potential Immunomodulator |
Authors: | DW, Damaiyanti Sari R.P, Sari R.P Muwarmanti D, Muwarmanti D |
Keywords: | Lemuru fish oil Eicosapentaenoic acid Docosahexaenoic acid Polyunsaturated fatty acid Toxicity |
Issue Date: | 2021 |
Abstract: | Background: Poly Unsaturated Fatty Acids have beneficial effects as an immunomodulator for periodontitis therapy. Lipid studies show that fish can be a unique source of polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid. Lemuru fish (Sardinella longicep) is one of fish that abbundant in Indonesia. Purpose: This study aims to find out the characterization and acute toxicity of lemuru fish oil for using in dental treatment. Methods: characterization study was tested using capillary gas chromatography coupled method with flame ionization. Acute toxicity performed by given lemuru orally with dose 174.1-917.3mg/20g mice weight for 24 hours observation and sacrificed for histopathology, meanwhile groups 96 hours observation continued. Result: Lemuru Fish oil contains 14.5% eicosapentaenoic acid and 13,2% Docosahexaenoic Acid. Acute toxicity showed the percentage of death below 50%, however, liver structure start to show an effect on dose 355.3mg/20gr Conclusion: Lemuru Fish oil had a component Poly Unsaturated Fatty Acids an potential immunomodulator. There was no acute toxicity found and the maximum dose without changing the microscopic structure of the liver is 174.1mg / 20gr Key words: Lemuru fish oil, Eicosapentaenoic acid, Docosahexaenoic acid, Polyunsaturated fatty acid, Toxicity. |
URI: | http://localhost:8080/xmlui/handle/123456789/7414 |
Appears in Collections: | VOL 13 NO 2 2021 |
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