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DC Field | Value | Language |
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dc.contributor.author | DW, Damaiyanti | - |
dc.contributor.author | Sari R.P, Sari R.P | - |
dc.contributor.author | Muwarmanti D, Muwarmanti D | - |
dc.date.accessioned | 2024-11-07T02:47:28Z | - |
dc.date.available | 2024-11-07T02:47:28Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/7414 | - |
dc.description.abstract | Background: Poly Unsaturated Fatty Acids have beneficial effects as an immunomodulator for periodontitis therapy. Lipid studies show that fish can be a unique source of polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid. Lemuru fish (Sardinella longicep) is one of fish that abbundant in Indonesia. Purpose: This study aims to find out the characterization and acute toxicity of lemuru fish oil for using in dental treatment. Methods: characterization study was tested using capillary gas chromatography coupled method with flame ionization. Acute toxicity performed by given lemuru orally with dose 174.1-917.3mg/20g mice weight for 24 hours observation and sacrificed for histopathology, meanwhile groups 96 hours observation continued. Result: Lemuru Fish oil contains 14.5% eicosapentaenoic acid and 13,2% Docosahexaenoic Acid. Acute toxicity showed the percentage of death below 50%, however, liver structure start to show an effect on dose 355.3mg/20gr Conclusion: Lemuru Fish oil had a component Poly Unsaturated Fatty Acids an potential immunomodulator. There was no acute toxicity found and the maximum dose without changing the microscopic structure of the liver is 174.1mg / 20gr Key words: Lemuru fish oil, Eicosapentaenoic acid, Docosahexaenoic acid, Polyunsaturated fatty acid, Toxicity. | en_US |
dc.subject | Lemuru fish oil | en_US |
dc.subject | Eicosapentaenoic acid | en_US |
dc.subject | Docosahexaenoic acid | en_US |
dc.subject | Polyunsaturated fatty acid | en_US |
dc.subject | Toxicity | en_US |
dc.title | Characterization and Acute Toxicity Bioactive Compound Canning Waste of Lemuru Fish Oil as Potential Immunomodulator | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 13 NO 2 2021 |
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