Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7414
Title: Characterization and Acute Toxicity Bioactive Compound Canning Waste of Lemuru Fish Oil as Potential Immunomodulator
Authors: DW, Damaiyanti
Sari R.P, Sari R.P
Muwarmanti D, Muwarmanti D
Keywords: Lemuru fish oil
Eicosapentaenoic acid
Docosahexaenoic acid
Polyunsaturated fatty acid
Toxicity
Issue Date: 2021
Abstract: Background: Poly Unsaturated Fatty Acids have beneficial effects as an immunomodulator for periodontitis therapy. Lipid studies show that fish can be a unique source of polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid. Lemuru fish (Sardinella longicep) is one of fish that abbundant in Indonesia. Purpose: This study aims to find out the characterization and acute toxicity of lemuru fish oil for using in dental treatment. Methods: characterization study was tested using capillary gas chromatography coupled method with flame ionization. Acute toxicity performed by given lemuru orally with dose 174.1-917.3mg/20g mice weight for 24 hours observation and sacrificed for histopathology, meanwhile groups 96 hours observation continued. Result: Lemuru Fish oil contains 14.5% eicosapentaenoic acid and 13,2% Docosahexaenoic Acid. Acute toxicity showed the percentage of death below 50%, however, liver structure start to show an effect on dose 355.3mg/20gr Conclusion: Lemuru Fish oil had a component Poly Unsaturated Fatty Acids an potential immunomodulator. There was no acute toxicity found and the maximum dose without changing the microscopic structure of the liver is 174.1mg / 20gr Key words: Lemuru fish oil, Eicosapentaenoic acid, Docosahexaenoic acid, Polyunsaturated fatty acid, Toxicity.
URI: http://localhost:8080/xmlui/handle/123456789/7414
Appears in Collections:VOL 13 NO 2 2021

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