Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7373
Title: Synthesis and Activity Test of 1-Allyl-3-(4-tertiary-Butylbenzoyl) Thioureaas a Candidate of an Analgesic Drug
Authors: Razak, Rais
Siswandono, Siswandono
Ekowati, Juni
Keywords: 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea,
drug candidate,
potential analgesic,
urea derivatives
Issue Date: 26-Apr-2022
Publisher: Faculty of Pharmacy Univesrsitas Airlangga
Abstract: Abstract Background: Urea derivatives showed good analgesic activity compared to diclofenac sodium. The addition of the allyl group to the thiourea and 4-tertiary-butylbenzoyl chlorideis expected to provide a better analgesic effect. Objective: The research aimed to synthesize 1-allyl-3-(4-tertiary-Butylbenzoyl) Thiourea and determine its analgesic activity in mice (Mus musculus). Methods: The synthesis was carried out by a modified SchottenBaumann reaction, via nucleophilic substitution reaction of allylthiourea on 4-tertiary-butylbenzoyl chloride. A writhing test was performed to observe analgesic activity in the test compound. Confirmation of the structure of pure 1-allyl-3-(4-tertiary-Butylbenzoyl) Thiourea was obtained through UV, IR, 1H-NMR, and 13C-NMR data. Results: The compound showed better pain inhibition activity compared to diclofenac sodium, with ED5019,018 mg/kg BW. Conclusion: The compound 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea showed better analgesic activity than diclofenac sodium. Keywords: 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea, drug candidate, potential analgesic, urea derivatives
URI: http://localhost:8080/xmlui/handle/123456789/7373
ISSN: 25808303
Appears in Collections:VOL 9 NO 1 2022

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