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DC Field | Value | Language |
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dc.contributor.author | Razak, Rais | - |
dc.contributor.author | Siswandono, Siswandono | - |
dc.contributor.author | Ekowati, Juni | - |
dc.date.accessioned | 2024-11-06T08:20:25Z | - |
dc.date.available | 2024-11-06T08:20:25Z | - |
dc.date.issued | 2022-04-26 | - |
dc.identifier.issn | 25808303 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/7373 | - |
dc.description.abstract | Abstract Background: Urea derivatives showed good analgesic activity compared to diclofenac sodium. The addition of the allyl group to the thiourea and 4-tertiary-butylbenzoyl chlorideis expected to provide a better analgesic effect. Objective: The research aimed to synthesize 1-allyl-3-(4-tertiary-Butylbenzoyl) Thiourea and determine its analgesic activity in mice (Mus musculus). Methods: The synthesis was carried out by a modified SchottenBaumann reaction, via nucleophilic substitution reaction of allylthiourea on 4-tertiary-butylbenzoyl chloride. A writhing test was performed to observe analgesic activity in the test compound. Confirmation of the structure of pure 1-allyl-3-(4-tertiary-Butylbenzoyl) Thiourea was obtained through UV, IR, 1H-NMR, and 13C-NMR data. Results: The compound showed better pain inhibition activity compared to diclofenac sodium, with ED5019,018 mg/kg BW. Conclusion: The compound 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea showed better analgesic activity than diclofenac sodium. Keywords: 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea, drug candidate, potential analgesic, urea derivatives | en_US |
dc.publisher | Faculty of Pharmacy Univesrsitas Airlangga | en_US |
dc.subject | 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea, | en_US |
dc.subject | drug candidate, | en_US |
dc.subject | potential analgesic, | en_US |
dc.subject | urea derivatives | en_US |
dc.title | Synthesis and Activity Test of 1-Allyl-3-(4-tertiary-Butylbenzoyl) Thioureaas a Candidate of an Analgesic Drug | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 9 NO 1 2022 |
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