Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7373
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dc.contributor.authorRazak, Rais-
dc.contributor.authorSiswandono, Siswandono-
dc.contributor.authorEkowati, Juni-
dc.date.accessioned2024-11-06T08:20:25Z-
dc.date.available2024-11-06T08:20:25Z-
dc.date.issued2022-04-26-
dc.identifier.issn25808303-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7373-
dc.description.abstractAbstract Background: Urea derivatives showed good analgesic activity compared to diclofenac sodium. The addition of the allyl group to the thiourea and 4-tertiary-butylbenzoyl chlorideis expected to provide a better analgesic effect. Objective: The research aimed to synthesize 1-allyl-3-(4-tertiary-Butylbenzoyl) Thiourea and determine its analgesic activity in mice (Mus musculus). Methods: The synthesis was carried out by a modified SchottenBaumann reaction, via nucleophilic substitution reaction of allylthiourea on 4-tertiary-butylbenzoyl chloride. A writhing test was performed to observe analgesic activity in the test compound. Confirmation of the structure of pure 1-allyl-3-(4-tertiary-Butylbenzoyl) Thiourea was obtained through UV, IR, 1H-NMR, and 13C-NMR data. Results: The compound showed better pain inhibition activity compared to diclofenac sodium, with ED5019,018 mg/kg BW. Conclusion: The compound 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea showed better analgesic activity than diclofenac sodium. Keywords: 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea, drug candidate, potential analgesic, urea derivativesen_US
dc.publisherFaculty of Pharmacy Univesrsitas Airlanggaen_US
dc.subject1-allyl-3-(4-tertiary-butylbenzoyl) thiourea,en_US
dc.subjectdrug candidate,en_US
dc.subjectpotential analgesic,en_US
dc.subjecturea derivativesen_US
dc.titleSynthesis and Activity Test of 1-Allyl-3-(4-tertiary-Butylbenzoyl) Thioureaas a Candidate of an Analgesic Drugen_US
dc.typeArticleen_US
Appears in Collections:VOL 9 NO 1 2022

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