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Title: | Synthesis and Activity Test of 1-Allyl-3-(4-tertiary-Butylbenzoyl) Thioureaas a Candidate of an Analgesic Drug |
Authors: | Razak, Rais Siswandono, Siswandono Ekowati, Juni |
Keywords: | 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea, drug candidate, potential analgesic, urea derivatives |
Issue Date: | 26-Apr-2022 |
Publisher: | Faculty of Pharmacy Univesrsitas Airlangga |
Abstract: | Abstract Background: Urea derivatives showed good analgesic activity compared to diclofenac sodium. The addition of the allyl group to the thiourea and 4-tertiary-butylbenzoyl chlorideis expected to provide a better analgesic effect. Objective: The research aimed to synthesize 1-allyl-3-(4-tertiary-Butylbenzoyl) Thiourea and determine its analgesic activity in mice (Mus musculus). Methods: The synthesis was carried out by a modified SchottenBaumann reaction, via nucleophilic substitution reaction of allylthiourea on 4-tertiary-butylbenzoyl chloride. A writhing test was performed to observe analgesic activity in the test compound. Confirmation of the structure of pure 1-allyl-3-(4-tertiary-Butylbenzoyl) Thiourea was obtained through UV, IR, 1H-NMR, and 13C-NMR data. Results: The compound showed better pain inhibition activity compared to diclofenac sodium, with ED5019,018 mg/kg BW. Conclusion: The compound 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea showed better analgesic activity than diclofenac sodium. Keywords: 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea, drug candidate, potential analgesic, urea derivatives |
URI: | http://localhost:8080/xmlui/handle/123456789/7373 |
ISSN: | 25808303 |
Appears in Collections: | VOL 9 NO 1 2022 |
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