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Title: | Protective cardiovascular benefits of exercise training as measured by circulating endothelial cells and high-density lipoprotein in adults |
Authors: | Kumboyono, Kumboyono Chomsy, Indah N. Firdaus, Dylan H. Setiawan, Meddy Wihastuti, Titin A. |
Keywords: | Aerobic exercise training Cardiovascular disease Cardiovascular protection Circulating endothelial cells High-density lipoprotein-cholesterol |
Issue Date: | 2022 |
Publisher: | Journal of Taibah University Medical Sciences |
Series/Report no.: | Original Article;701-706 |
Abstract: | Objective: This study aims to determine the protective cardiovascular effect of aerobic exercise training by measuring cluster of differentiation 146 (CD146), circulating endothelial cell (CEC), and high-density lipoprotein- cholesterol (HDL-C) levels in adults. Methods: This study was an experimental pre-post-test without a control group. Forty-five participants were divided into three groups based on aerobic exercise training intensity: low, moderate, and high. Whole blood samples were measured for HDL-C levels. In addition, CEC was isolated from Peripheral Blood Mononuclear Cells (PBMC) samples, then identified by CD146 marker using flow cytometry. Results: CEC percentage and HDL-C increase after aerobic exercise training. There was a significant difference in CEC percentage between the intensity groups. However, there was no difference in HDL-C levels. Conclusion: Aerobic exercise training can protect cardiovascular health by stimulating CEC mobilization, identified by CD146. In addition, an HDL-C level increase also contributes to cardiovascular protection by decreasing inflammation levels, inhibiting low-density lipoproteincholesterol oxidation, improving endothelial regeneration capabilities, and lowering blood glucose. |
URI: | http://localhost:8080/xmlui/handle/123456789/7293 |
ISSN: | 1658-3612 |
Appears in Collections: | Vol 17 No 4 (2022) |
Files in This Item:
File | Description | Size | Format | |
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701-706.pdf | 701-706 | 1.15 MB | Adobe PDF | View/Open |
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