Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7293
Title: Protective cardiovascular benefits of exercise training as measured by circulating endothelial cells and high-density lipoprotein in adults
Authors: Kumboyono, Kumboyono
Chomsy, Indah N.
Firdaus, Dylan H.
Setiawan, Meddy
Wihastuti, Titin A.
Keywords: Aerobic exercise training
Cardiovascular disease
Cardiovascular protection
Circulating endothelial cells
High-density lipoprotein-cholesterol
Issue Date: 2022
Publisher: Journal of Taibah University Medical Sciences
Series/Report no.: Original Article;701-706
Abstract: Objective: This study aims to determine the protective cardiovascular effect of aerobic exercise training by measuring cluster of differentiation 146 (CD146), circulating endothelial cell (CEC), and high-density lipoprotein- cholesterol (HDL-C) levels in adults. Methods: This study was an experimental pre-post-test without a control group. Forty-five participants were divided into three groups based on aerobic exercise training intensity: low, moderate, and high. Whole blood samples were measured for HDL-C levels. In addition, CEC was isolated from Peripheral Blood Mononuclear Cells (PBMC) samples, then identified by CD146 marker using flow cytometry. Results: CEC percentage and HDL-C increase after aerobic exercise training. There was a significant difference in CEC percentage between the intensity groups. However, there was no difference in HDL-C levels. Conclusion: Aerobic exercise training can protect cardiovascular health by stimulating CEC mobilization, identified by CD146. In addition, an HDL-C level increase also contributes to cardiovascular protection by decreasing inflammation levels, inhibiting low-density lipoproteincholesterol oxidation, improving endothelial regeneration capabilities, and lowering blood glucose.
URI: http://localhost:8080/xmlui/handle/123456789/7293
ISSN: 1658-3612
Appears in Collections:Vol 17 No 4 (2022)

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