Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7199
Title: Optimasi Formula Emulgel Vitamin C dengan Pendekatan Simplex Lattice Design
Authors: Taufik, Irfan Imam
Soewandhi, Sundani Nurono
Nugraha, Yuda Prasetya
Keywords: optimization
vitamin C
design of experiment
simplex lattice design
copolymer
Issue Date: Apr-2023
Publisher: Jurnal Sains Farmasi & Klinis
Citation: Original Article
Abstract: Vitamin C in the cosmetics is known to have many benefits such as a brightening agent, anti-aging and preventing black spots on facial skin. However, vitamin C preparations are easily oxidized and change color in the product, so that a stabilizer is needed to maintain the stability of vitamin C during use and storage. This study aims to determine the effect of hydroxyethyl acrylate/sodium acryloyldimethyl taurate hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer (EMT-10) and sodium metabisulfite on characteristics vitamin C emulgel formulas and determine the optimum emulgel formula through the Design of Experiment (DOE) approach with the Simplex Lattice Design method. Based on study showed that the variable concentrations of (EMT-10) and sodium metabisulfite had a significant effect on viscosity (P<0.05), aroma (hedonic) test (P< 0.05), texture testing (P<0.05), and formula stability (P<0.05). For the variable concentration of EMT-10 and sodium metabisulfite, it did not significantly affect the pH value (P>0.05). The atingoptimum formulation is a composition of 2.305% EMT-10 and 0.194% sodium metabisulfite with a pH response of 4.13, viscosity of 22,547 cps, product color stability with a score of 2, aroma test with a score of 2.29, and texture test with a score of 3.21. The results of testing for pH, viscosity, texture and color stability of the product met the acceptance range, but the aroma needed to be improved to increase the preference score for vitamin C emulgel product
URI: http://localhost:8080/xmlui/handle/123456789/7199
Appears in Collections:VOL 10 NO 1 2023

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