Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/5056
Title: Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids
Authors: Turner, Laurent
Santosa, Sylvia
Keywords: physical activity
dietary fatty acids
bariatric surgery
macrophages
adipose tissue characteristics
meta-inflammation
Issue Date: 2021
Publisher: Advances in Nutrition
Series/Report no.: Review;1893-1910
Abstract: With increasing adiposity in obesity, adipose tissue macrophages contribute to adipose tissue malfunction and increased circulating proinflammatory cytokines. The chronic low-grade inflammation that occurs in obesity ultimately gives rise to a state of metainflammation that increases the risk of metabolic disease. To date, only lifestyle and surgical interventions have been shown to be somewhat effective at reversing the negative consequences of obesity and restoring adipose tissue homeostasis. Exercise, dietary interventions, and bariatric surgery result in immunomodulation, and for some individuals their effects are significant with or without weight loss. Robust evidence suggests that these interventions reduce chronic inflammation, in part, by affecting macrophage infiltration and promoting a phenotypic switch from the M1- to M2- like macrophages. The purpose of this review is to discuss the impact of dietary fatty acids, exercise, and bariatric surgery on cellular characteristics affecting adipose tissue macrophage presence and phenotypes in obesity.
URI: http://localhost:8080/xmlui/handle/123456789/5056
Appears in Collections:VOL 12 NO 6 (2021)

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