Perspective:MethionineRestriction–Induced Longevity—APossibleRoleforInhibitingthe SynthesisofBacterialQuorumSensingMolecules

Abstract

Methionine restriction (MR) extends lifespans in multiple species through mechanisms that include enhanced oxidative stress resistance and inhibitionofinsulin/insulin-likegrowthfactorI(IGF-I)signaling.MethionineandS-adenosylmethionine(SAM)aretheessentialprecursorsofbacterial quorum sensing (QS) molecules, and therefore, MR might also affect bacterial communication to prevent enteric bacterial infection as well as chronicinflammation,whichcontributestolifespanprolongation.Here,wediscusstheinfluenceofMRonoxidativestressresistanceandinhibition of insulin/IGF-I cell signaling and further propose a potential mechanism involving bacterial QS inhibition for lifespan extension. Unraveling the connection between MR and inhibition of QS provides new strategies for combating infectious diseases, resulting in enriched understanding of MR-inducedlifespanextension.