Vaginal endometrial stromal sarcoma: A literature review

Abstract

Vaginal endometrial stromal sarcoma: A literature review Wu Hongwena,1, Luo Yib,1, Yin Nanlina, Gui Wenwua, Cao Yib,* a Reproductive Medical Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China b Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing China A R T I C L E I N F O Article history: Received 13 March 2019 Received in revised form 23 August 2019 Accepted 25 August 2019 Available online 27 August 2019 Keywords: Vaginal endometrial stromal sarcoma Malignant transformation of endometriosis Vaginal sarcoma Endometrial stromal sarcoma A B S T R A C T Vaginal endometrial stromal sarcoma (VESS) is a rare disease. To the best of our knowledge, there have only been a few reported cases in the literature. Therefore, we conducted a literature review to obtain specific knowledge of this disease. Thirteen cases of VESS were found by searching the Medline and EMBASE databases in the English language. The mechanism of VESS may be associated with endometriosis, and its diagnosis largely depends on pathological examination because it has no typical symptoms. Treatment of VESS incorporates surgery, chemotherapy, radiotherapy, and hormonal therapy. Some novel drugs targeting its mechanism may become alternative therapies. Its prognostic factors may include tumor stage and the expression of hormonal receptors.