Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/9673
Title: Peripheral Classic and Intermediate Monocyte Subsets as Immune Biomarkers of Systemic Lupus Erythematosus Disease Activity
Authors: Oehadian, Amaylia
Ghozali, Mohammad
Kusuma, Sutiadi
Mersiana, Lusi
Gita Ghassani, Nadia
Fransisca, Fransisca
Millenard Sigilipu, Yitzchak
Kartikasari, Andini
Hamijoyo, Laniyati
Keywords: Monocyte subset, SLE, Classical monocytes, Intermediate monocytes, Disease activity
Issue Date: 2024
Abstract: Background: Monocytes are evolutionarily preserved innate immune cells that play essential roles in immune response regulation. Three activated monocyte subsets—classical (CD14++CD16–), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++)—are associated with systemic lupus erythematosus (SLE) progression. This study aims to determine the association of monocyte subsets with SLE disease activity. Methods: A cross-sectional study involving 25 patients with SLE was conducted. Blood samples were collected, and monocyte subsets were identified using flow cytometry. Patients were grouped by disease activity using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) into inactive (SLEDAI-2K ≤ 4) and active (SLEDAI-2K > 4). The cutoff for monocyte subsets was determined using Receiver Operating Characteristic (ROC) analysis. Results: Nine active and 16 inactive subjects were identified. Compared with individuals without active disease, individuals with active disease had significantly lower mean classical monocyte subsets (71.9% vs 88%, p = 0.008), and higher median intermediate monocytes (29.1% vs 11.1%, p = 0.019). The median nonclassical monocyte subsets were not significantly different between the two groups. The cutoff for classical monocytes in active disease was ≤72.2%, AUC = 0.788, p = 0.021, with 66.7% sensitivity and 87.5% specificity; for intermediate monocytes, it was >22.3%, AUC = 0.788, p = 0.014, with 66.7% sensitivity and 100% specificity. Conclusion: Classical and intermediate monocytes could be considered as immune cellular markers for identifying active SLE. Keywords: Monocyte subset, SLE, Classical monocytes, Intermediate monocytes, Disease activity
URI: http://localhost:8080/xmlui/handle/123456789/9673
Appears in Collections:VOL 56 NO 4 2024

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