Molecular Docking and ADME Studies of Centella Asiatica as Anti Hyperuricemia

Abstract

Centella asiatica is a traditional natural medicine used in a number of Southeast Asian nations. (also known as Centella asiatica L., Urb., or Gotu Kola). The aim of this study is to determine the antihyperuricemia properties of Centella asiatica extract and the possibility that they will interact with the XDH enzyme. The XDH enzyme is one of three enzymes that can influence the onset of hyperuricemia with the other two are SLC22A12 and ABCG2. In this research, we employ a computational method in collaboration with a number of applications and databases. ADME analysis was carried on for some Centella asiatica constituents to determine their similarities to the drug and bioavailability components. The analysis continued on with molecular docking between the chemical compounds and several enzymes related to hyperuricemia. According to the findings, Centella asiatica contains active constituents that can be used as an alternative therapy for hyperuricemia. Key words: Centella asiatica, Hyperuricemia, Molecular docking