Assessing the utilization of antimicrobial agents in pediatric pneumonia during the era of the 13-valent pneumococcal conjugate vaccine: A retrospective, single-center study

Abstract

Abstract Background and purpose: Pneumonia and bronchopneumonia are the most common infectious diseases in children. This study aimed to analyze changes in causative pathogens and antibiotic use for bronchopneumonia or pneumonia after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in children. Methods: This retrospective study was conducted from 2009 to 2019. Hospitalized children aged 6 monthse3 years with a discharge diagnosis of bronchopneumonia or pneumonia were included to analyze changes in the potential mismatch between the diagnosed pathogen and antibiotic use. Results: The cohort comprised 1100 patients, including 648 (59%) and 452 (41%) with a discharge diagnosis of bronchopneumonia and pneumonia, respectively. The trend of viral pneumonia increased every year (rs Z 0.101, p < 0.05) Antibiotics were administered in 97% patients, with an increasing annual trend in macrolide use (rs Z 0.031, p Z 0.009). Regarding antibiotic utilization, no significant variations were observed in the days of therapy (DOT) (rs Z 0.076, p Z 0.208) or length of therapy (LOT) (rs Z 0.027, p Z 0.534) per patient-year throughout the study duration. Interestingly, the LOT for combined therapy with macrolides and first-line beta-lactams was high (rs Z 0.333, p Z 0.028). In viral pneumonia treatment, neither the DOT nor LOT exhibited significant variations (rs Z 0.006, p Z 0.787 and rs Z 0.156, p Z 0.398).