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dc.contributor.authorKim, Si-Ho-
dc.contributor.authorJeon, Minji-
dc.contributor.authorJang, Sukbin-
dc.contributor.authorMun, Seok Jun-
dc.date.accessioned2024-12-20T04:03:14Z-
dc.date.available2024-12-20T04:03:14Z-
dc.date.issued2023-10-
dc.identifier.citationOriginal Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9437-
dc.description.abstractbstract Background: The criteria for antibiotic failure in persistent Staphylococcus aureus bacteremia (SAB) are unclear, but treatment response and bacteremia duration are commonly used indicators of antibiotic failure. We evaluated the effects of treatment response and bacteremia duration on mortality in persistent SAB. Methods: We retrospectively identified patients with persistent SAB in four universityaffiliated hospitals between 2017 and 2021. Bacteremia duration was calculated from the first day of active antibiotic therapy, and persistent SAB was defined as bacteremia lasting for 2 or more days. Defervescence and Pitt bacteremia score (PBS) were used to evaluate treatment response at treatment day 4. The primary outcome was 30-day in-hospital mortality. Timedependent multivariable Cox regression analysis and subgroup analysis according to methicillin resistance were performed. Results: A total of 221 patients was included in the study, and the 30-day in-hospital mortality was 28.5%. There was no significant difference in bacteremia duration between survived and deceased patients. Independent factors for mortality included age, Charlson comorbidity index, initial PBS, pneumonia, and removal of the eradicable focus. PBS at treatment day 4 3 was the strongest risk factor (adjusted hazard ratio [HR] Z 4.260), but defervescence was not. Bacteremia duration was not an independent factor except for 13 days or more of methicillin-resistant SAB (adjusted HR Z 1.064). Conclusions: In patients with persistent SAB, PBS at treatment day 4 was associated with 30- day in-hospital mortality rather than defervescence and bacteremia duration. The results of this study could help determine early intensified treatment strategies in persistent SAB patients.en_US
dc.language.isoen_USen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectBacteremiaen_US
dc.subjectPersistent infectionen_US
dc.subjectMortalityen_US
dc.subjectRisk factorsen_US
dc.titleFactors for mortality in patients with persistent Staphylococcus aureus bacteremia: The importance of treatment response rather than bacteremia durationen_US
dc.typeArticleen_US
Appears in Collections:VOL 56 NO 5 2023

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