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dc.contributor.authorLin, Donna Shu-Han-
dc.contributor.authorTzeng, Shian Chiuan-
dc.contributor.authorCha, Tai-Lung-
dc.contributor.authorHung, Chin-Mao-
dc.contributor.authorLin, Wen-Chin-
dc.contributor.authorYang, Chuen-Mi-
dc.date.accessioned2024-12-20T03:47:23Z-
dc.date.available2024-12-20T03:47:23Z-
dc.date.issued2023-10-
dc.identifier.citationOriginal Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9430-
dc.description.abstractAbstract Background: Effective therapy for COVID-19 remains limited. Hydroxychloroquine (HCQ) has been considered, but safety and efficacy concerns remain. Chitosan exhibits antiviral and immunomodulatory effects, yet how the combination of HCQ and chitosan performs in treating COVID-19 is unknown. Methods: Male Syrian hamsters were inoculated intranasally with standardized stocks of the SARS-CoV-2 virus. Hamsters were allocated to saline (PBS), chitosan oligosaccharide (COS), HCQ, or COS þ HCQ groups and received corresponding drugs. On days 1, 7, and 14 postinfection, two animals from each group were euthanized for sample collection. Viral loads were measured in lung homogenates. Biochemistry markers, cytokines, and immunoglobulins were analyzed from hamster sera. HCQ concentrations were compared between the blood, bronchoalveolar lavage, and lung tissues. All groups underwent histopathology exams of the lungs. Additional hamsters were treated with the same drugs to assess for toxicities to the heart and liveren_US
dc.language.isoen_USen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectChitosan oligosaccharideen_US
dc.subjectHydroxychloroquineen_US
dc.subjectDrug inhalationen_US
dc.titleInhalable chitosan-based hydrogel as a mucosal adjuvant for hydroxychloroquine in the treatment for SARS-CoV-2 infection in a hamster modelen_US
dc.typeArticleen_US
Appears in Collections:Vol. 56 No. 5 (2023)

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