Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/9426
Full metadata record
DC FieldValueLanguage
dc.contributor.authorYu, Su-Yeon-
dc.contributor.authorChoi, Miyoung-
dc.contributor.authorCheong, Chelim-
dc.contributor.authorRyoo, Seungeun-
dc.contributor.authorHuh, Kyungmin-
dc.contributor.authorYoon, Young Kyung-
dc.date.accessioned2024-12-20T03:19:55Z-
dc.date.available2024-12-20T03:19:55Z-
dc.date.issued2023-10-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9426-
dc.description.abstractAbstract This study evaluated the efficacy and safety of neutralizing monoclonal antibodies (mAbs) with usual care in patients with coronavirus disease 2019 (COVID-19). Randomized controlled trials comparing the efficacy and safety of neutralizing mAb treatment in patients with COVID-19 were identified using electronic database searches through March 10, 2023. This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Overall, 13 trials (23 articles) involving 25,646 patients were included in this systematic review. Compared with usual care, neutralizing mAbs were associated with significantly reduced all-cause mortality in outpatients with COVID-19 (pooled risk ratios [RR], 0.41; 95% confidence interval (CI), 0.20e0.83; 12 studies), but not in inpatients. In the subgroup analysis, only outpatients infected prior to the emergence of Delta variant or those with mAbeVOC match had significantly reduced mortality, while no significant benefit was observed in patients infected with Delta and posteDelta variants or mAbeVOC mismatch. Moreover, the rate of hospitalization and number of hospital visits had significantly reduced only in outpatients infected prior to the emergence of the Delta variant and those with mAbeVOC match. Our systematic review used majority of the high-certainty evidence. Our study found neutralizing mAbs were beneficial for outpatients infected prior to Delta variant or mAbeVOC match. In the face of the continuous emergence of new COVID-19 variants, additional clinical data are needed to determine whether neutralizing mAb treatment will be effective for the newly emerging variants.en_US
dc.language.isoen_USen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectCOVID-19en_US
dc.subjectNeutralizing monoclonal antibodyen_US
dc.subjectMeta-analysisen_US
dc.subjectSystematic reviewen_US
dc.subjectGRADEen_US
dc.titleClinical efficacy and safety of SARS-CoV-2- neutralizing monoclonal antibody in patients with COVID-19: A living systematic review and meta-analysisen_US
dc.typeArticleen_US
Appears in Collections:VOL 56 NO 5 2023

Files in This Item:
File Description SizeFormat 
909-920.pdf2.11 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.