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dc.contributor.authorChang Huang, Ruei--
dc.contributor.author-Hsiang Chiu, Chun-
dc.contributor.author-Sheng Shang, Hung-
dc.contributor.author-Lih Perng, Cherng-
dc.contributor.authorTa Chiang, Tsung--
dc.contributor.author-Chou Tsai, Chun-
dc.date.accessioned2024-12-20T02:19:58Z-
dc.date.available2024-12-20T02:19:58Z-
dc.date.issued2022-12-01-
dc.identifier.issn1684-1182-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9413-
dc.description.abstractAbstract Background/Purpose: Clinical characteristics of patients in the first community outbreak of coronavirus disease 2019 (COVID-19) by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant B.1.1.7 in Taiwan have not been characterized. Methods: SARS-CoV-2 positive specimens from inpatients between May 7 and June 15 in 2021were screen for SARS-CoV-2 B.1.1.7 lineage by VirSNiP assay. Clinical characteristics were reviewed and compared with those from Feb 1 to April 30, 2020 and from Jan 1 to March 31, 2022. Results: One hundred forty-one inpatients from May 7 to June 15, 2021 infected with SARS-CoV-2 B.1.1.7 lineage were included. The major presenting symptoms were fever (88.7%) and cough (59.6%). Incidence of relevant complications including pulmonary embolism, simultaneous infections with bacteria, virus, and fungi were 0.7%, 12.8%, 13.5%, and 2.1%, respectively. Old age, high Charlson comorbidity index, short of breath, and initial critical illness were independently associated with 28-day mortality (all p < 0.05). In comparison to COVID-19 inpatients from Feb 1 to April 30, 2020, patients from the outbreak by SARS-CoV-2 B.1.1.7 lineage were older, more severe in disease condition, higher mortality but less obvious initial presenting symptoms. After implementation of nationwide vaccination campaign in the next half year of 2021, COVID-19inpatients from Jan 1 to March 31 in 2022 indicated less severe diseases than those infected with SARS-CoV-2 B.1.1.7 lineage.en_US
dc.language.isoenen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectCOVID-19en_US
dc.subject; SARS-COV-2;en_US
dc.subjectB.1.1.7; B.1.1.529;en_US
dc.subjectTaiwan;en_US
dc.subjectCharacteristicsen_US
dc.titleClinical characteristics analysis of COVID-19 patients from the first significant community outbreak by SARS-CoV-2 variant B.1.1.7 in Taiwan as experienced from a single northern medical centeren_US
dc.typeArticleen_US
Appears in Collections:VOL 55 NO 6 Part 1 2022

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