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DC Field | Value | Language |
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dc.contributor.author | Ruenjaiman, Vichaya | - |
dc.contributor.author | Sodsai, Pimpayao | - |
dc.contributor.author | Kueanjinda, Patipark | - |
dc.contributor.author | Bunrasmee, Worawan | - |
dc.contributor.author | Klinchanhom, Siriwan | - |
dc.contributor.author | Reantragoon, Rangsima | - |
dc.date.accessioned | 2024-12-20T02:09:20Z | - |
dc.date.available | 2024-12-20T02:09:20Z | - |
dc.date.issued | 2022-12-01 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9409 | - |
dc.description.abstract | Abstract Backgrounds: SARS-CoV-2 infection results in a broad spectrum of clinical outcomes, ranging from asymptomatic to severe symptoms and death. Most COVID-19 pathogenesis is associated with hyperinflammatory conditions driven primarily by myeloid cell lineages. The long-term effects of SARS-CoV-2 infection post recovery include various symptoms. Methods: We performed a longitudinal study of the innate immune profiles 1 and 3 months after recovery in the Thai cohort by comparing patients with mild, moderate, and severe clinical symptoms using peripheral blood mononuclear cells (n Z 62).Results: Significant increases in the frequencies of monocytes compared to controls and NK cells compared to mild and moderate patients were observed in severe patients 1e3 months post recovery. Increased polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) were observed in all recovered patients, even after 3 months. Increased IL-6 and TNFa levels in monocytes were observed 1 month after recovery in response to lipopolysaccharide (LPS) stimulation, while decreased CD86 and HLA-DR levels were observed regardless of stimulation. A multiplex analysis of serum cytokines performed at 1 month revealed that most innate cytokines, except for TNFa, IL4/IL-13 (Th2) and IFNg (Th1), were elevated in recovered patients in a severity-dependent manner. Finally, the myelopoiesis cytokines G-CSF and GM-CSF were higher in all patient groups. Increased monocytes and IL-6- and TNFa-producing cells were significantly associated with long COVID-19 symptoms. Conclusions: These results reveal that COVID-19 infection influences the frequencies and functions of innate immune cells for up to 3 months after recovery, which may potentially lead to some of the long COVID symptoms. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Taiwan LLC | en_US |
dc.subject | COVID-19; | en_US |
dc.subject | Innate immune cells; | en_US |
dc.subject | Lipopolysaccharide; | en_US |
dc.subject | Post recovery | en_US |
dc.title | Impact of SARS-CoV-2 infection on the profiles and responses of innate immune cells after recovery | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 55 NO 6 Part 1 2022 |
Files in This Item:
File | Description | Size | Format | |
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993-1004.pdf | 4.17 MB | Adobe PDF | View/Open |
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