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DC Field | Value | Language |
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dc.contributor.author | Yan, Zheng | - |
dc.contributor.author | Luo, Xu-Feng | - |
dc.contributor.author | Yao, Shu-Na | - |
dc.contributor.author | Wang, Hai-Ying | - |
dc.contributor.author | Chu, Jun-Feng | - |
dc.contributor.author | Zhao, Shuang | - |
dc.date.accessioned | 2024-12-19T07:42:32Z | - |
dc.date.available | 2024-12-19T07:42:32Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.citation | Original Article | en_US |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9374 | - |
dc.description.abstract | Abstract Background: More and more novel anticancer drugs have been approved for patients with hematological malignancies in recent years, but HBV reactivation (HBV-R) data in this population is very scarce. This study aimed to evaluated HBV-R risk in patients with hematological malignancies receiving novel anticancer drugs. Methods: HBV markers and serum HBV DNA levels of patients with hematological malignancies receiving novel anticancer drugs in a tertiary cancer hospital were retrospectively collected. HBV-R risk in the whole cohort and subgroups was described. The relevant literature was reviewed to make a pooled analysis. Results: Of 845 patients receiving novel anticancer drugs, 258 (30.5%) were considered at risk for HBV-R. The median duration of exposure to novel drugs was 5.6 (0.1e67.6) months. The incidence of HBV-R was 2.1% in patients with past HBV infection without prophylactic antiviral treatment (PAT) and 1.2% in all patients at risk of HBV-R. In a pooled analysis of 11 studies with 464 patients, the incidence of HBV-R was 2.4% (95% CI: 1.3e4.2) in all at-risk patients receiving novel anticancer drugs and 0.6% (95% CI: 0.03e3.5) in patients with anticancer drugs plus PAT. The incidence of death due to HBV-R was 0.4% (95% CI: 0.1e1.6) in all at-risk patients and 18.2% (95% CI: 3.2e47.7) in patients with HBV-R. Conclusion: Most episodes of HBV-R are preventable, and most cases with HBV-R are manageable. We recommend that novel anticancer drugs should not be intentionally avoided when treating cancer patients with HBV infection. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier Taiwan LLC | en_US |
dc.subject | Hematological malignancy | en_US |
dc.subject | HBV reactivation | en_US |
dc.subject | Lymphoma | en_US |
dc.subject | Novel anticancer drug | en_US |
dc.subject | Incidence | en_US |
dc.title | Low incidence of hepatitis B virus reactivation in patients with hematological malignancies receiving novel anticancer drugs: A report from a high epidemic area and literature review | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 56 NO 4 2023 |
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File | Description | Size | Format | |
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747-756.pdf | 687.69 kB | Adobe PDF | View/Open |
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