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DC Field | Value | Language |
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dc.contributor.author | Tsai, Ching-Yen | - |
dc.contributor.author | Chen, Guan-Jhou | - |
dc.contributor.author | Tsai, Chin-Shiang | - |
dc.contributor.author | Liou, Bo-Huang | - |
dc.contributor.author | Yang, Chia-Jui | - |
dc.contributor.author | Tsai, Hung-Chin | - |
dc.date.accessioned | 2024-12-19T07:24:35Z | - |
dc.date.available | 2024-12-19T07:24:35Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.citation | Original Article | en_US |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9369 | - |
dc.description.abstract | Abstract Background: The short-term impact of sofosbuvir (SOF)-based direct-acting antivirals (DAAs) combined with antiretroviral therapy (ART) on renal function in patients with HIV/ HCV-coinfection remains controversial. Methods: This multicenter, retrospective study aimed to sequentially record the estimated glomerular filtration rate (eGFR) at baseline, end of therapy (EOT), 12 weeks off-treatment (SVR12), and at time points after SVR12 (post-SVR12) and to identify the factors associated with an eGFR decline to <60 ml/min/1.73 m2 in HIV/HCV-coinfected patients receiving DAAs. The evolution of mean eGFRs between different ART and DAAs combinations among patients of different HIV transmission routes were compared using a generalized linear mixed effects model. The periods between baseline and EOT, between EOT and post-SVR12, and between baseline and post-SVR12 were defined as the on-treatment, post-treatment, and all-course periods, respectively. Acute kidney disease (AKD) was defined as a decline of eGFR to <60 ml/ min/1.73 m2 . Result: A total of 445 patients with baseline eGFRs >60 ml/min/1.73 m2 were included. We found that eGFRs declined during the on-treatment period in the tenofovir-containing ART and SOF-based DAA groups. There were no differences in the slope coefficient during the on-treatment and post-treatment periods among all risk groups except for people who inject drug. Increasing age and plasma HIV RNA >20 copies/ml before DAA treatment were factors independently associated with AKD during the on-treatment period while increasing age was independently associated with AKD during the all-course period. Conclusion: Only increasing age was an independent factor associated with AKD among HIV/ HCV-coinfected patients during and after DAA treatments. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier Taiwan LLC | en_US |
dc.subject | Renal function | en_US |
dc.subject | Acute kidney disease | en_US |
dc.subject | Ageing | en_US |
dc.subject | Sofosbuvir | en_US |
dc.subject | Tenofovir | en_US |
dc.title | Evolution of estimated glomerular filtration rate in HIV/HCV-coinfected patients who received direct-acting antivirals: A multicenter retrospective study | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 56 NO 4 2023 |
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718-728.pdf | 702.23 kB | Adobe PDF | View/Open |
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