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dc.contributor.authorLai, Jiun-Ji-
dc.contributor.authorSiu, L. Kristopher-
dc.contributor.authorChang, Feng-Yee-
dc.contributor.authorLin, Jung-Chung-
dc.contributor.authorYu, Ching-Mei-
dc.contributor.authorWu, Rui-Xin-
dc.date.accessioned2024-12-19T06:28:55Z-
dc.date.available2024-12-19T06:28:55Z-
dc.date.issued2023-06-
dc.identifier.citationOriginal Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9350-
dc.description.abstractAbstract Background/purpose: The study was to assess the relationship between antibiotic therapy and the outcome in intensive care unit (ICU) patients with Stenotrophomonas maltophilia bloodstream infection (BSI). Methods: ICU patients with monomicrobial S. maltophilia BSI from January 2004 to December 2019 were included and divided into two groupsdthose with- and without appropriate antibiotic therapy after BSIdfor comparison. The primary outcome was the relationship between appropriate antibiotic therapy and 14-day mortality. The secondary outcome was the influence of different antibiotic therapies: levofloxacin- and trimethoprimesulfamethoxazole (TMP/ SMX)-containing regimens, on 14-day mortality. Results: A total of 214 ICU patients were included. Patients received appropriate antibiotic therapy (n Z 133) after BSI had a lower 14-day mortality than those (n Z 81) without appropriate antibiotic therapy (10.5% vs. 46.9%, p < 0.001). No difference on 14-day mortality between groups of patients by time of appropriate antibiotic therapy was observed (p > 0.05). After a propensity score matching, the results is consistent that 14-day mortality were lower in patients with appropriate antibiotic therapy than those without appropriate antibiotic therapy (11.5% vs. 39.3%, p < 0.001). Among patients with S. maltophilia BSI receiving appropriate antibiotic therapy, there was a trend levofloxacin-containing regimens is associated with lower mortality than TMP/SMX-containing regimens (HR 0.233, 95% CI 0.050e1.084, p Z 0.063). Conclusion: Appropriate antibiotic therapy was associated with decreased 14-day mortality in ICU patients with S. maltophilia BSI regardless of time. Levofloxacin-containing regimens may be better choice than TMP/SMX -containing regimens in treating ICU patients with S. maltophilia BSI.en_US
dc.language.isoen_USen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectBloodstream infectionen_US
dc.subjectBacteremiaen_US
dc.subjectStenotrophomonas maltophiliaen_US
dc.subjectLevofloxacinen_US
dc.subjectTrimethoprime sulfamethoxazoleen_US
dc.subjectAntibiotic therapyen_US
dc.subjectIntensive careen_US
dc.titleAppropriate antibiotic therapy is a predictor of outcome in patients with Stenotrophomonas maltophilia blood stream infection in the intensive care uniten_US
dc.typeArticleen_US
Appears in Collections:VOL 56 NO 3 2023

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