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dc.contributor.authorHuang, Yen-Fang-
dc.contributor.authorHsu, Fang-Chi-
dc.contributor.authorWu, Jiunn-Jong-
dc.contributor.authorLin, Yi-Ling-
dc.contributor.authorLiu, Ming-Tsan-
dc.contributor.authorYang, Chin-Hui-
dc.date.accessioned2024-12-19T04:24:34Z-
dc.date.available2024-12-19T04:24:34Z-
dc.date.issued2023-06-
dc.identifier.citationOriginal Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9323-
dc.description.abstractAbstract Background: Understanding the neutralizing antibody (NAb) titer against COVID-19 over time is important to provide information for vaccine implementation. The longitudinal NAb titer over one year after SARS-CoV-2 infection is still unclear. The purposes of this study are to evaluate the duration of the neutralizing NAb titers in COVID-19 convalescents and factors associated with the titer positive duration. Methods: A cohort study followed COVID-19 individuals diagnosed between 2020 and 2021 May 15th from the COVID-19 database from the Taiwan Centers for Disease Control. We analyzed NAb titers from convalescent SARS-CoV-2 individuals. We used generalized estimating equations (GEE) and a Cox regression model to summarize the factors associated with NAb titers against COVID-19 decaying in the vaccine-free population. Results: A total of 203 convalescent subjects with 297 analytic samples were followed for a period of up to 588 days. Our study suggests that convalescent COVID-19 in individuals after more than a year and four months pertains to only 25% of positive titers. The GEE model indicates that longer follow-up duration was associated with a significantly lower NAb titer. The Cox regression model indicated the disease severity with advanced condition was associated with maintaining NAb titers (adjusted hazard ratio: 2.01, 95% CI: 1.11e3.63) and that smoking was also associated with higher risk of negative NAb titers (adjusted hazard ratio: 0.55, 95% CI: 0.33e0.92). Conclusions: Neutralizing antibody titers diminished after more than a year. The antibody titer response against SARS-CoV-2 in naturally convalescent individuals provides a reference for vaccinations.en_US
dc.language.isoen_USen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectSARS-CoV-2en_US
dc.subjectCOVID-19en_US
dc.subjectDisease severityen_US
dc.subjectNeutralizing antibody titeren_US
dc.titleLongitudinal neutralizing antibody responses after SARS-CoV-2 infection: A convalescent cohort study in Taiwanen_US
dc.typeArticleen_US
Appears in Collections:VOL 56 NO 2 2023

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