Please use this identifier to cite or link to this item:
http://localhost:8080/xmlui/handle/123456789/9319
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tsai, Ming-Han | - |
dc.contributor.author | Shih, Hsiang-Ju | - |
dc.contributor.author | -Wen Su, Kuan | - |
dc.contributor.author | Liao, Sui-Ling | - |
dc.contributor.author | Chin Hua, Man- | - |
dc.contributor.author | Chieh Yao, Tsung- | - |
dc.date.accessioned | 2024-12-19T04:08:15Z | - |
dc.date.available | 2024-12-19T04:08:15Z | - |
dc.date.issued | 2022-08-01 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9319 | - |
dc.description.abstract | Abstract Background: Airway microbiota may play an important role in regulating the immune response related to allergic respiratory diseases. A molecular-based approach was used to analyze the association between nasopharyngeal microbiota, serum immunoglobin (Ig)E levels, and childhood respiratory allergies. Methods: Nasopharyngeal swabs were collected from children aged 36 months with three phenotypes, including allergic respiratory diseases plus atopy, atopy alone, and healthy controls for microbiome analysis using Illumina-based 16S rRNA gene sequencing. Results: In total, 87 children were enrolled, including 36 with allergic respiratory diseases plus atopy, 21 with atopy alone, and 30 healthy controls. Proteobacteria (45.7%), Firmicutes (29.3%), and Actinobacteria (15.3%) were the most prevalent phyla in the study population. Compared with healthy controls, a lower Chao1 index was found in children with allergies (P < 0.035), indicating that bacterial richness was inversely associated with airway allergiesAdditionally, in comparison with healthy controls, the genera Acinetobacter, Moraxella, Asaia, and Rhodococcus were more abundant and positively correlated with total serum IgE levels in children with allergies (P < 0.01), whereas the genera Enterococcus and Rickettsia were inversely correlated with total IgE levels, and also appeared to be negatively associated with airway allergies (P < 0.01). Conclusions: The composition of the nasopharyngeal microbiota alteration may have an influence on childhood respiratory allergies. The inverse association between bacterial richness and allergies postulated that children living in a microbially hygienic environment may increase their risk of developing respiratory allergies. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Taiwan LLC | en_US |
dc.subject | Airway allergies; | en_US |
dc.subject | Children; | en_US |
dc.subject | Microbiota; | en_US |
dc.subject | Nasopharynx | en_US |
dc.title | Nasopharyngeal microbial profiles associated with the risk of airway allergies in early childhood | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 55 NO 4 2022 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
777-785.pdf | 974.25 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.