Antidiabetic Activity and Phytochemical Constituents of Syzygium cumini Leave in Kadipaten, Central Java Indonesia, Indonesia

Abstract

Introduction: Ethnomedicaly, jamblang (java plum) has been used as antidiabetic treatment in Dayak Tribe. This study aims to evaluate the effectiveness and the safety of the jamblang leaf extract as an antidiabetic. Objective: Evaluate Effecticity of Syzigium cumini (java plum) as anti-diabetic herb. Method: The antidiabetic activity test, used an animal model which gaven food a high fat diet High Fat Diet (HFD) then it was induced with Streptozotocin injected intraperitoneally. The subjects used in the study were male rats (Ratus novergicus) Sprague-Dawley strain. Results: Oral administration of jamblang extract has anti hyperglycemic activity through decrease of fasting blood glucose point significantly (dose 1, 50mg/ Kg Bw p: <0.0001, dose 2, 100 mg/Kg BW p: <0.0001). Key words: Syzigium cumini, Anti-hyperglicemic, Fasting blood glucose.