The Cytotoxicity Study of Lantana camara Linn Essential Oil on HeLa Cancer Cells Line

Abstract

Lantana camara Linn (Verbenaceae) is a natural plant that thrives in tropical climates and is relatively easy to cultivate. In Indonesia, this plant is still often considered as a weed. When held, the unpleasant smell and sticky hand make people dislike this plant even though the flowers are diverse. The essential oil was extracted from the leaves of L. camara by hydrodistillation. This study aimed to see how cytotoxic L. camara essential oil was against HeLa carcinoma cells. This research aimed to discover if L. camara essential oil was cytotoxic to HeLa cancer cells. The GC-MS investigation of an essential oil recognized ten compounds; two main constituents of the oil were Caryophyllene (27.65%) and Germacrene D (23.01%). The essential oil showed cytotoxicity on HeLa cervical cancer cell lines. The cytotoxic effect of oil was determined using MTT, IC50 values were 44.86 μg/mL + 0.07. Key word: Cytotoxicity, HeLa, Hydrodistillation, Lantana camara, Cervical cancer.