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dc.contributor.authorYan, Meng-Yao-
dc.contributor.authorHe, Yuan-Hui-
dc.contributor.authorRuan, Gen-Jie-
dc.contributor.authorXue, Feng-
dc.contributor.authorZheng, Bo-
dc.contributor.authorLv, Yuan-
dc.date.accessioned2024-12-19T03:03:53Z-
dc.date.available2024-12-19T03:03:53Z-
dc.date.issued2023-04-
dc.identifier.citationOriginal Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9288-
dc.description.abstractAbstract Background: Vancomycin-resistant Enterococcus (VRE) can be carried in the gut for a long period and its carriage status is associated with subsequent infections. This study aimed to investigate the frequency of intestinal VRE carriage in intensive care patients in Beijing. Methods: A multicenter, retrospective cross-sectional study was conducted at six hospitals in Beijing, China. All patients admitted to intensive care units (ICUs) between April 2 and May 1, 2017, were enrolled, and their clinical data were gathered by reviewing electronic medical records. Rectal swabs collected from patients were stored at 80 C in the Institute of Clinical Pharmacology, Peking University First Hospital, and they were selectively cultured for VRE, then the identified strains were analyzed by polymerase chain reaction (PCR) to detect the glycopeptide resistance gene and were characterized by multilocus sequence typing (MLST). Results: Of 148 patients recruited, 46 (31.1%) carried VRE, with the majority (n Z 42) being Enterococcus faecium. In total, 78.3% of the VRE were vanA positive and 15.2% vanM positive, while 6.5% undetected glycopeptide resistance gene. The predominant ST was ST78 (47.6%) followed by ST192 (14.3%), ST555 (9.5%), and ST789 (9.5%). Multivariate analysis showed that factors associated VRE carriage were patients aged >65 years (odds ratio [OR], 3.786; 95% confidence interval [CI], 1.402e10.222) and recent third-generation cephalosporins use (OR, 6.360; 95% CI, 1.873e21.601). Conclusions: The overall proportion of VRE carriage in patients admitted to ICUs was markedly high in Beijing, China. The vanM gene has been spread widely but vanA gene was the dominant resistance determinant in VRE in Beijing.en_US
dc.language.isoen_USen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectVancomycin-resistant Enterococcusen_US
dc.subjectCarriageen_US
dc.subjectMolecular epidemiologyen_US
dc.subjectIntensive care patientsen_US
dc.titleThe prevalence and molecular epidemiology of vancomycin-resistant Enterococcus (VRE) carriage in patients admitted to intensive care units in Beijing, Chinaen_US
dc.typeArticleen_US
Appears in Collections:VOL 56 NO 2 2023

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