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dc.contributor.authorAi, Ming-Ying-
dc.contributor.authorLu, Huai-En-
dc.contributor.authorLee, Wan-Yu-
dc.contributor.authorLiu, Hsin-Yi-
dc.contributor.authorChuang, Han-Chuan-
dc.contributor.authorChen, Bi-Li-
dc.contributor.authorWang, Er-Ying-
dc.date.accessioned2024-12-19T02:59:44Z-
dc.date.available2024-12-19T02:59:44Z-
dc.date.issued2023-04-
dc.identifier.citationOriginal Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9287-
dc.description.abstractAbstract Introduction: The significantly higher mortality rate in the critical illness patients with Pseudomonas aeruginosa (PA) infection is linked to inappropriate selecting of empirical treatment. Traditional local antibiogram provides clinicians the resistant rate of a single antimicrobial agent to the pathogen in the specific setting. The information is valuable to the clinicians in selecting suitable empirical antibiotic therapy. However, traditional local antibiogram can only provide information for single agent empirical antibiotic not combination regimens. The combination antibiogram should be developed to facilitate the selection of appropriate antibiotics to broader the coverage rate of resistant PA. Methods: The susceptibility to the b-lactam antibiotics (piperacillin/tazobactam (PTZ), ceftazidime, cefepime, imipenem, or meropenem) or to those administered in combination with an aminoglycoside (gentamicin or amikacin) or fluoroquinolone (ciprofloxacin or levofloxacin) was calculated. The chi-square test was used to compare the differences of combination coverage rates between non-ICU and ICU isolates. Results: 880 PA isolates were isolated during study period. The susceptibility of single agents ranged from 83.1% to 89.7%. The combination regimens containing amikacin provide the highest cover rate (98.9%e99.1%) and those containing levofloxacin provide less coverage rate (92.3%e93.9%). The susceptibility to five b-lactam single agents in ICU isolates significantly lower than non-ICU isolates. The non-ICU isolates exhibited significantly higher susceptibility to the PTZegentamicin (p Z 0.002) and ceftazidimeegentamicin (p Z 0.025) than ICU isolates. Conclusion: Our results support the use of aminoglycosides instead of fluoroquinolones as additive agents in empirical combination treatments for patients with critical infections caused by PA.en_US
dc.language.isoen_USen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectPseudomonas aeruginosa (PAen_US
dc.subjectCombination antibiogramen_US
dc.subjectEmpirical combination regimenen_US
dc.subjectExpand coverage rateen_US
dc.titleDevelopment of a combination antibiogram for empirical treatments of Pseudomonas aeruginosa at a university-affiliated teaching hospitalen_US
dc.typeArticleen_US
Appears in Collections:VOL 56 NO 2 2023

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