Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/9284
Title: Immunostimulant Activity of Pegagan Embun Herbs Extract (Hydrocotyle sibthorpioides Lam.) With Carbon Clearance Method Towards Male White Mice
Authors: Afriwardi, Afriwardi
Fitri, Afdhila
Husni, Elidahanum
Badriyya, Elsa
Aldi, Yufri
Keywords: Hydrocotyle sibthorpioides Lam., Immunostimulants, Carbon clearance, Leukocyte, Eosinophil, Neutrophil, Lymphocytes
Issue Date: 2021
Abstract: Pegagan embun (Hydrocotyle sibthorpioides L.) has been used traditionally to cure various diseases such as anti-inflammatory, neutralizing toxins, dysentery, and others. This study aims to determine the immunostimulant effect of pegagan embun herbs extract using the carbon clearance method, the number, and the percentage of leukocyte cells. In this study, 25 male white mice were used, which were divided into five groups, groups 1, 2, and 3 given pegagan embun herbs extract in a dose of 10 mg/kgbw; 50 mg/ kgbw; 200 mg/kgbw, group 4 was given 0,5% Na CMC, and group 5 were given stimuno 50 mg/kgbw. The preparation is given orally for seven consecutive days. On the eighth day, the phagocytosis index, number, and percentage of leukocyte cells were determined. The results showed that pegagan embun herbs extract has immunostimulant activity. The phagocytosis index of the 10 mg/kgbw dose group is 1.0211, 1.27796 for the 50 mg/kgbw, and 1.5250 for the 200 mg/kgbw. Then, the number of leukocytes of the 10, 500, and 200 mg/kgbw are 8.820/μL, 9.906/μL, and 10.790/μL, respectively. The percentage of lymphocyte cells are 58,5%, 60,6% and 62,8%, and for segment neutrophil cells were 26%, 27,6% and 30% for group 10, 50, and 200 mg/kgbw extract. Based on the results, that the pegagan embun herbs extract has immunostimulant activity against male white mice. Key words: Hydrocotyle sibthorpioides Lam., Immunostimulants, Carbon clearance, Leukocyte, Eosinophil, Neutrophil, Lymphocytes.
URI: http://localhost:8080/xmlui/handle/123456789/9284
Appears in Collections:VOL 13 NO 6 2021

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