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DC Field | Value | Language |
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dc.contributor.author | Lee, Chun Yi | - |
dc.contributor.author | Sung, Chia Hsin | - |
dc.contributor.author | Wu, Meng Che | - |
dc.contributor.author | Chang, Yu Chuan | - |
dc.contributor.author | Chang, Jih Chin | - |
dc.date.accessioned | 2024-12-19T02:37:32Z | - |
dc.date.available | 2024-12-19T02:37:32Z | - |
dc.date.issued | 2023-04 | - |
dc.identifier.citation | Original Article | en_US |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9273 | - |
dc.description.abstract | Abstract Background: Viral bronchiolitis presents a heterogeneous spectrum. In this study, we investigated the clinical characteristics and the cytokines/chemokines profiles among respiratory syncytial virus (RSV), rhinovirus (RV), and their dual infection in Taiwanese children with viral bronchiolitis. Method: This study was conducted between October 2014 and June 2017. Viral etiology was identified using a Luminex respiratory virus panel and blood cytokines were evaluated using a MILLIPLEX MAP Human Cytokine/Chemokine Panel. Cytokine/Chemokine expressions were compared by clinical severity, steroid treatment, and viral entities. Results: A total of 184 patients were evaluated; at least one respiratory virus was identified in 163 (88.6%) patients. RSV and RV were the two leading viral etiologies, with 25.5% and 17.3%, respectively. RV bronchiolitis has a comparable severity to RSV but is more common in children of an older age with a history of recurrent wheezing and blood eosinophilia. Decreased tumor necrosis factor-alpha (TNF-a) and interferon gamma (INF-g) levels were correlated with clinical severity. Patients infected with RV exhibited higher levels of Interleukin (IL)-22, IL-23, IL-25, IL-31, and IL-33 (p < 0.05), whereas those with RSV had higher levels of TNF-a, INF-g, and IL-10 (p < 0.05). Systemic steroid treatment was associated with higher expressions of IL-4, IL-8, IL-13, and MIP-1a levels (p < 0.05). Cluster analysis revealed a high correlation of IL33 and IL-31(R2 Z 0.9731, p < 0.0001). Conclusion: Different viral infections elicited the characteristic clinical presentation and immune profiles in bronchiolitis. Our findings also highlight the role of the IL-33/IL-31 axis in the immunopathogenesis of bronchiolitis. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier Taiwan LLC | en_US |
dc.subject | Bronchiolitis | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Respiratory syncytial virus | en_US |
dc.subject | Rhinovirus | en_US |
dc.title | Clinical characteristics and differential cytokine expression in hospitalized Taiwanese children with respiratory syncytial virus and rhinovirus bronchiolitis | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 56 NO 2 2023 |
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File | Description | Size | Format | |
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282-291.pdf | 1.61 MB | Adobe PDF | View/Open |
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