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dc.contributor.authorChong, Chen Hui-
dc.contributor.authorLiu, Chun-Eng-
dc.contributor.authorLeong, Yin-Yee-
dc.contributor.authorLiao, Siang-Ying-
dc.contributor.authorLai, Huei-Wen-
dc.contributor.authorLee, Yu-Lin-
dc.date.accessioned2024-12-19T02:28:44Z-
dc.date.available2024-12-19T02:28:44Z-
dc.date.issued2023-04-
dc.identifier.citationOriginal Articleen_US
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/9265-
dc.description.abstractAbstract Background: Healthcare workers (HCWs) without evidence of immunity to varicella-zoster virus (VZV) are recommended to undergo varicella vaccination. Immunogenicity of live attenuated varicella vaccine has rarely been investigated among HCWs in Taiwan. Methods: Anti-VZV immunoglobulin G (IgG) titer was checked for all HCWs at Changhua Christian Hospital from 2011 to 2017. One-dose and two-dose (separated by 4e8 weeks) vaccines were administered to HCWs with equivocal and negative anti-varicella IgG results, respectively. Follow-up anti-VZV IgG was determined at least 4 weeks after completion of vaccination. Factors associated with seroconversion to varicella vaccination were analyzed. Results: Among 2406 included HCWs, the anti-VZV IgG serostatus was tested positive, equivocal and negative in 1924 (79.9%), 117 (4.9%) and 365 (15.2%), respectively. The seroprevalence had decreased from 88.0% (235/267) in 2011 to 72.2% (270/374) in 2017 (p for trend <0.05). A total of 67.8% (327/482) HCWs completed scheduled vaccination and serological follow-up. The seroconversion rates for HCWs with baseline equivocal and negative anti-VZV IgG results were 100% (80/80) and 79.4% (196/247) after one- and two-dose vaccination, respectively. In multivariate analysis, obesity (adjusted odds ratio, 0.308; 95% confidence interval [CI], 0.11e0.94, p Z 0.039) was the only factor statistically significantly associated with seroconversion to vaccination. Conclusion: Decreasing trends of seroprevalence of VZV were observed among HCWs from 2011 to 2017. HCWs who were obese were less likely to respond to varicella vaccination.en_US
dc.language.isoen_USen_US
dc.publisherElsevier Taiwan LLCen_US
dc.subjectChickenpoxen_US
dc.subjectVaccinationen_US
dc.subjectSeroresponseen_US
dc.subjectSeroconversionen_US
dc.subjectNosocomial infectionen_US
dc.titleSeroprevalence of varicella-zoster virus antibody and immunogenicity of live attenuated varicella vaccine in healthcare workers in Taiwanen_US
dc.typeArticleen_US
Appears in Collections:VOL 56 NO 2 2023

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