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DC Field | Value | Language |
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dc.contributor.author | Salsabila, Korrie | - |
dc.contributor.author | Tofriska Paramaiswari, Wisiva | - |
dc.contributor.author | Amalia, Hafsah | - |
dc.contributor.author | Ruyani, Akhmad | - |
dc.contributor.author | Tafroji, Wisnu | - |
dc.contributor.author | Winarti, Yayah | - |
dc.contributor.author | Majid Khoeri, Miftahuddin | - |
dc.date.accessioned | 2024-12-18T04:41:57Z | - |
dc.date.available | 2024-12-18T04:41:57Z | - |
dc.date.issued | 2022-06-01 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/9236 | - |
dc.description.abstract | Abstract Background: Streptococcus pneumoniae is a bacterial pathogen that colonizes the human nasopharynx. Colonization is frequently reported to be high in young children. In this study, we investigated the nasopharyngeal (NP) carriage rate, serotype distribution, and antibiotic susceptibility of S. pneumoniae in children under five years of age in Kotabaru, South Kalimantan, Indonesia. Methods: NP swab specimens were collected from 399 young children (mean age: 30 months) who participated in the Rampa Village Community Health Center, with 74% of the participants being Bajau children. S. pneumoniae was identified using optochin susceptibility and bile solubility tests. Serotyping was performed by sequential multiplex PCR, and antimicrobial susceptibility profiling was performed by disk diffusion and microdilution methods. Results: The NP carriage rate of S. pneumoniae was 45% (180/399). The most commonly serotypes were 6A/6B (18%), followed by 15B/15C (17%), 19F (16%), 34 (8%), and 23F (5%); 46% of them were identified as strains of the PCV13 vaccine type. Additionally, almost half of the pneumococcal isolates were non-susceptible to penicillin (40%), whereas non-susceptibility to tetracycline (36.8%), trimethoprim/sulfamethoxazole (29.7%), erythromycin (16.8%), chloramphenicol (9.7%), and clindamycin (8.6%) was also found. We identified 18% (n Z 34) of S. pneumoniae isolates as multidrug-resistant (MDR) strains, and serotype 19F was the most common (74%) among them.Conclusions: MDR S. pneumoniae vaccine type strains were dominated by serotype 19F. The implementation of a pneumococcal conjugate vaccine program in Indonesia might reduce MDR strains circulating in the community in the future | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Taiwan LLC | en_US |
dc.subject | Antimicrobial resistance; | en_US |
dc.subject | Carriage; | en_US |
dc.subject | Children; | en_US |
dc.subject | Serotype; | en_US |
dc.subject | Streptococcus pneumoniae | en_US |
dc.title | Nasopharyngeal carriage rate, serotype distribution, and antimicrobial susceptibility profile of Streptococcus pneumoniae isolated from children under five years old in Kotabaru, South Kalimantan, Indonesia | en_US |
dc.type | Article | en_US |
Appears in Collections: | VOL 55 NO 3 2022 |
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File | Description | Size | Format | |
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482-488.pdf | 456.11 kB | Adobe PDF | View/Open |
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